#ppiposseofpicks: 32-38 (.457)
#ppiupsetalert: 6-8 (.429)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FOX | #18 Villanova | #1 Kansas | -2 | 2 | #ppiupsetalert, #ppiposseofpicks: Villanova #104 |
| 12 PM | BTN | #14 Michigan | Presbyterian College | 29.5 | 37 | #ppiposseofpicks: Michigan -29.5 |
| 12 PM | FS2 | #19 Florida State (N) | South Florida (N) | 10 | 10 | |
| 1 PM | ESPN3 | #11 Memphis | Jackson State | 27.5 | 24 | |
| 1 PM | SECN+ | #21 Tennessee | Jacksonville State | 19 | 19 | |
| 1 PM | Youngstown State | #25 West Virginia | -12.5 | -13 | ||
| 2 PM | #24 Texas Tech | UT-Rio Grande Valley | 24 | 18 | #ppiposseofpicks: UT-Rio Grande Valley +24 | |
| 2:30 PM | BTN | #17 Butler (N) | Purdue (N) | 1.5 | 6 | #ppiposseofpicks: Butler -1.5 |
| 5 PM | Gonzaga | Eastern Washington | 20 | 20 | ||
| 5:15 PM | CBS | #5 Ohio State (N) | #6 Kentucky (N) | 4.5 | 8 | |
| 6 PM | SECN | Auburn | Lehigh | 24 | 26 | |
| 6:30 PM | CBSSN | #13 Dayton (N) | Colorado (N) | 5 | 5 | |
| 6:30 PM | PAC12 | #20 San Diego State (N) | Utah (N) | 7.5 | 11 | |
| 7 PM | BTN | #15 Michigan State | Eastern Michigan | 23 | 12 | #ppiposseofpicks: Eastern Michigan +23 |
| 10 PM | ESPN2 | #16 Arizona (N) | St. John’s (N) | 11 | 12 | |
| 10:30 PM | PAC12 | #8 Oregon | Texas Southern | 26.5 | 24 | |
| 12 PM | ESPN2 | Wichita State | VCU | 5.5 | 5 | |
| 12 PM | ESPN+ | George Washington | Harvard | 6.5 | -5 | #ppiposseofpicks: Harvard +6.5 |
| 12 PM | ESPN+ | La Salle | Fairleigh Dickinson | 11 | 24 | #ppiposseofpicks: La Salle -11 |
| 2 PM | ESPN+ | Rhode Island | Western Kentucky | 5.5 | 4 | |
| 2:30 PM | Duquesne | Austin Peay | 9.5 | 14 | ||
| 3 PM | Middle Tennessee | St. Bonaventure | -4.5 | -6 | ||
| 4 PM | ESPN+ | George Mason | UMBC | 10 | 22 | #ppiposseofpicks: George Mason -10 |
| 7 PM | ESPN+ | Kansas State (N) | Saint Louis (N) | 1 | -10 | #ppiposseofpicks: Saint Louis +104 |
| 12 PM | ESPN | Indiana | Notre Dame | 3 | 3 | |
| 12 PM | ACCN | Wake Forest | North Carolina A&T | 18.5 | 19 | |
| 2 PM | ACCN | Miami (FL) | Coppin State | 17.5 | 17 | |
| 3 PM | CBS | North Carolina (N) | UCLA (N) | 5.5 | 3 | #ppiposseofpicks: UCLA +155 |
| 4 PM | ACCN | Virginia Tech | VMI | 19 | 22 | |
| 5:30 PM | PAC12 | Boston College (N) | California (N) | 1 | 0 | |
| 6 PM | ACCN | Syracuse | North Florida | 14 | 13 | |
| 12 PM | ESPN2 | Wichita State | VCU | 5.5 | 5 | |
| 1 PM | ESPN3 | Temple | Rider | 9 | 8 | |
| 1 PM | Tulane (N) | Towson (N) | 7 | |||
| 2 PM | Oklahoma | UCF | 10.5 | 6 | ||
| 2:30 PM | ESPN3 | Tulsa | Colorado State | 3 | 3 | |
| 9 PM | BTN | Iowa | Cincinnati | 3 | 5 | |
| 2 PM | FOX | Providence | Texas | 1 | -9 | #ppiposseofpicks: Texas +1 |
| 5:30 PM | ESPN2 | Oklahoma State | Minnesota | 3.5 | 11 | #ppiposseofpicks: Oklahoma State -3.5 |
| 12 PM | FS1 | Georgetown | Samford | 16.5 | 24 | #ppiposseofpicks: Georgetown -16.5 |
| 8:30 PM | PAC12 | Arizona State | Creighton | 3 | 7 | |
| 8:30 PM | CBSSN | DePaul | Northwestern | 6.5 | 18 | #ppiposseofpicks: DePaul -6.5 |
| 1 PM | SECN | Illinois | Missouri | 3.5 | 4 | |
| 5 PM | BTN | Wisconsin | Milwaukee | 16 | 15 | |
| 6 PM | Nebraska | North Dakota | 10 | 5 | #ppiposseofpicks: North Dakota +10 | |
| 3 PM | PAC12 | Stanford (N) | San Diego (N) | 9.5 | 13 | |
| 7 PM | Washington State | Incarnate Word | 21 | 25 | ||
| 8:30 PM | SECN | Texas A&M | Oregon State | -5.5 | -6 | |
| 9 PM | FS1 | USC | LSU | -2 | 9 | #ppiposseofpicks: USC +110 |
| 2 PM | SECN+ | Ole Miss | SE Louisiana | 20.5 | 20 | |
| 3:30 PM | SECN | Alabama | Belmont | 0 | 2 | |
| 8 PM | Valparaiso | Arkansas | -13.5 | -7 | #ppiposseofpicks: Valpariaso +13.5 | |
| 8 PM | SECN+ | Vanderbilt | UNC Wilmington | 15 | 15 |