#ppiupsetalert record: 40-59 (.404), #ncaavsspread: 29-33 (.467)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 2:15 PM | CBS | #1 Michigan | #6 Tennessee | 8.5 | 8 | Midwest Elite 8 (Chicago): Tennessee +8.5 |
| 5:05 PM | CBS | #1 Duke | #2 Connecticut | 5.5 | 5 | East Elite 8 (Washington, DC): Connecticut +5.5 |
#ppiupsetalert record: 40-59 (.404), #ncaavsspread: 29-31 (.483)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:09 PM | TBS | #3 Illinois | #9 Iowa | 6.5 | 5 | South Elite 8 (Houston), Iowa +6.5 |
| 8:49 PM | TBS | #1 Arizona | #2 Purdue | 5.5 | 4 | West Elite 8 (San Jose), Purdue +5.5 |
#ppiupsetalert record: 40-59 (.404), #ncaavsspread: 25-31 (.446)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7:10 PM | CBS | #1 Duke | #5 St. John’s | 6.5 | 4 | East Sweet 16 (Washington, DC): St. John’s +6.5 |
| 7:35 PM | TBS | #1 Michigan | #4 Alabama | 9.5 | 13 | Midwest Sweet 16 (Chicago): Michigan -9.5 |
| 9:45 PM | CBS | #2 Connecticut | #3 Michigan State | 2.5 | 4 | East Sweet 16 (Washington, DC): Connecticut -2.5 |
| 10:05 PM | TBS | #2 Iowa State | #6 Tennessee | 3.5 | 1 | Midwest Sweet 16 (Chicago): #ppiupsetalert, Tennessee +3.5 |
#ppiupsetalert record: 40-59 (.404), #ncaavsspread: 24-28 (.462)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7:10 PM | CBS | #2 Purdue | #11 Texas | 7.5 | 13 | West Sweet 16 (San Jose): Purdue -7.5 |
| 7:30 PM | TBS | #4 Nebraska | #9 Iowa | 1.5 | 3 | South Sweet 16 (Houston): Nebraska -1.5 |
| 9:45 PM | CBS | #1 Arizona | #4 Arkansas | 8.5 | 9 | West Sweet 16 (San Jose): Arizona -8.5 |
| 10:05 PM | TBS | #2 Houston | #3 Illinois | 2.5 | 7 | South Sweet 16 (Houston): Houston -2.5 |
#ppiupsetalert record: 39-59 (.398), #ncaavsspread: 19-25 (.432)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #2 Purdue | #7 Miami (FL) | 7.5 | 7 | West Rd 2 (St. Louis), Purdue -7.5 |
| 2:45 PM | CBS | #2 Iowa State | #7 Kentucky | 4.5 | 4 | Midwest Rd 2 (St. Louis), Kentucky +4.5 |
| 5:15 PM | CBS | #4 Kansas | #5 St. John’s | -3.5 | -5 | East Rd 2 (San Diego), #ppiupsetalert, St. John’s -166 |
| 6:10 PM | TNT | #3 Virginia | #6 Tennessee | -1.5 | 5 | Midwest Rd 2 (Philadelphia), Virginia -106 |
| 7:10 PM | TBS | #1 Florida | #9 Iowa | 10.5 | 6 | South Rd 2 (Tampa), Iowa +10.5 |
| 7:50 PM | TruTV | #1 Arizona | #9 Utah State | 11.5 | 7 | West Rd 2 (San Diego), Utah St +11.5 |
| 8:45 PM | TNT | #2 Connecticut | #7 UCLA | 4.5 | 6 | East Rd 2 (Philadelphia), UConn -4.5 |
| 7:50 PM | TruTV | #4 Alabama | #5 Texas Tech | -1.5 | 0 | Midwest Rd 2 (Tampa), Alabama -104 |
#ppiupsetalert record: 39-58 (.402), #ncaavsspread: 17-19 (.472)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #1 Michigan | #9 Saint Louis | 12.5 | 8 | Midwest Rd 2 (Buffalo), Saint Louis +12.5 |
| 2:45 PM | CBS | #3 Michigan State | #6 Louisville | 4.5 | 5 | East Rd 2 (Buffalo), Michigan St -4.5 |
| 5:15 PM | CBS | #1 Duke | #9 TCU | 11.5 | 6 | East Rd 2 (Greenville), TCU +11.5 |
| 6:10 PM | TNT | #2 Houston | #10 Texas A&M | 10.5 | 8 | South Rd 2 (Oklahoma City), Texas A&M +10.5 |
| 7:10 PM | TruTV/TBS | #3 Gonzaga | #11 Texas | 6.5 | 7 | West Rd 2 (Portland), Gonzaga -6.5 |
| 7:50 PM | CBS | #3 Illinois | #11 VCU | 10.5 | 4 | South Rd 2 (Greenville), VCU +10.5 |
| 8:45 PM | TNT | #4 Nebraska | #5 Vanderbilt | -1.5 | -2 | South Rd 2 (Oklahoma City), #ppiupsetalert, Vanderbilt -130 |
| 9:45 PM | Tru/TV/TBS | #4 Arkansas | #12 High Point | 11.5 | 8 | West Rd 2 (Portland), High Point +11.5 |
#ppiupsetalert record: 37-53 (.411), #ncaavsspread: 11-9 (.550)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:15 PM | CBS | #7 Kentucky | #10 Santa Clara | 2.5 | -3 | Midwest Rd 1 (St. Louis), #ppiupsetalert, Santa Clara +128 |
| 12:40 PM | TruTV | #5 Texas Tech | #12 Akron | 7.5 | -5 | Midwest Rd 1 (Tampa), #ppiupsetalert, Akron +250 |
| 1:35 PM | TNT | #1 Arizona | #16 Long Island | 30.5 | 23 | West Rd 1 (San Diego), Long Island +30.5 |
| 1:50 PM | TBS | #3 Virginia | #14 Wright State | 17.5 | 15 | Midwest Rd 1 (Philadelphia), Wright St +17.5 |
| 2:50 PM | CBS | #2 Iowa State | #15 Tennessee State | 24.5 | 15 | Midwest Rd 1 (St. Louis), Tennessee St +24.5 |
| 3:15 PM | TruTV | #4 Alabama | #13 Hofstra | 11.5 | 1 | Midwest Rd 1 (Tampa), #ppiupsetalert, Hofstra +540 |
| 4:10 PM | TNT | #8 Villanova | #9 Utah State | -1.5 | -5 | West Rd 1 (San Diego), #ppiupsetalert, Utah St -130 |
| 4:25 PM | TBS | #6 Tennessee | #11 Miami (OH) | 11.5 | 2 | Midwest Rd 1 (Philadelphia), #ppiupsetalert, Miami (OH) +530 |
| 6:50 PM | TNT | #8 Clemson | Iowa | 2.5 | -3 | South Rd 1 (Tampa), #ppiupsetalert, Iowa -138 |
| 7:10 PM | CBS | #5 St. John’s | #12 Northern Iowa | 9.5 | 9 | West Rd 1 (San Diego), Northern Iowa +9.5 |
| 7:25 PM | TBS | #7 UCLA | #10 UCF | 5.5 | 2 | East Rd 1 (Philadelphia), #ppiupsetalert, UCF +195 |
| 7:35 PM | TruTV | #2 Purdue | #15 Queens University | 25.5 | 20 | West Rd 1 (St. Louis), Queens University +25.5 |
| 9:25 PM | TNT | #1 Florida | #16 Prairie View A&M | 35.5 | 22 | South Rd 1 (Tampa), Prairie View A&M +35.5 |
| 9:45 PM | CBS | #4 Kansas | #13 California Baptist | 14.5 | 6 | West Rd 1 (San Diego), Cal Baptist +14.5 |
| 10 PM | TBS | #2 Connecticut | #15 Furman | 20.5 | 15 | East Rd 1 (Philadelphia), Furman +20.5 |
| 10:10 PM | TruTV | #7 Miami (FL) | #10 Missouri | 1.5 | 5 | West Rd 1 (St. Louis), Miami (FL) -1.5 |
#ppiupsetalert record: 34-52 (.395), #ncaavsspread: 2-2 (.500)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:15 PM | CBS | #8 Ohio State | #9 TCU | 2.5 | 0 | East Rd 1 (Greenville), #ppiupsetalert, TCU 120 |
| 12:40 PM | TruTV | #4 Nebraska | #13 Troy | 13.5 | 12 | South Rd 1 (Oklahoma City), Troy +13.5 |
| 1:30 PM | TNT | #6 Louisville | #11 South Florida | 4.5 | -2 | East Rd 1 (Buffalo), #ppiupsetalert, South Florida +150 |
| 1:50 PM | TBS | #5 Wisconsin | #12 High Point | 10.5 | 8 | West Rd 1 (Portland), High Point +10.5 |
| 2:50 PM | CBS | #1 Duke | #16 Siena | 28.5 | 15 | East Rd 1 (Greenville), Siena +28.5 |
| 3:15 PM | TruTV | #5 Vanderbilt | #12 McNeese | 12.5 | 7 | South Rd 1 (Oklahoma City), McNeese +12.5 |
| 4:05 PM | TNT | #3 Michigan State | #14 North Dakota State | 15.5 | 9 | East Rd 1 (Buffalo), North Dakota St +15.5 |
| 4:25 PM | TBS | #4 Arkansas | #13 Hawaii | 14.5 | 11 | West Rd 1 (Portland), Hawaii +14.5 |
| 6:50 PM | TNT | #6 North Carolina | #11 VCU | 2.5 | -4 | South Rd 1 (Greenville), #ppiupsetalert, VCU +126 |
| 7:10 PM | CBS | #1 Michigan | #16 Howard | 31.5 | 22 | Midwest Rd 1 (Buffalo), Howard +31.5 |
| 7:25 PM | TBS | #6 BYU | #11 Texas | 2.5 | 0 | West Rd 1 (Portland), #ppiupsetalert, Texas +114 |
| 7:35 PM | TruTV | #7 Saint Mary’s | #10 Texas A&M | 2.5 | 4 | South Rd 1 (Oklahoma City), Saint Mary’s -2.5 |
| 9:25 PM | TNT | #3 Illinois | #14 Pennsylvania | 25.5 | 16 | South Rd 1 (Greenville), Pennsylvania +25.5 |
| 9:45 PM | CBS | #8 Georgia | #9 Saint Louis | 2.5 | -3 | Midwest Rd 1 (Buffalo), Saint Louis +116 |
| 10 PM | TBS | #3 Gonzaga | #14 Kennesaw State | 20.5 | 14 | West Rd 1 (Portland), Kennesaw St +20.5 |
| 10:10 PM | TruTV | #2 Houston | #15 Idaho | 23.5 | 18 | South Rd 1 (Oklahoma City), Idaho +23.5 |
#ppiupsetalert record: 34-52 (.395)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:40 PM | TruTV | #16 Prairie View A&M | #16 Lehigh | -2.5 | 0 | South Region – First Four, Prairie View +2.5 |
| 9:15 PM | TruTV | #11 Miami (OH) | #11 SMU | -7.5 | 2 | Midwest Region – First Four, Miami (OH) +245 |
#ppiupsetalert record: 34-52 (.395)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:40 PM | TruTV | UMBC | Howard | 1.5 | 2 | Midwest Region – First Four, UMBC -1.5 |
| 9:15 PM | TruTV | NC State | Texas | 1.5 | 4 | West Region – First Four, NC State -1.5 |