#ppiupsetalert record: 34-52 (.395), #ncaavsspread: 2-2 (.500)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:15 PM | CBS | #8 Ohio State | #9 TCU | 2.5 | 0 | East Rd 1 (Greenville), #ppiupsetalert, TCU 120 |
| 12:40 PM | TruTV | #4 Nebraska | #13 Troy | 13.5 | 12 | South Rd 1 (Oklahoma City), Troy +13.5 |
| 1:30 PM | TNT | #6 Louisville | #11 South Florida | 4.5 | -2 | East Rd 1 (Buffalo), #ppiupsetalert, South Florida +150 |
| 1:50 PM | TBS | #5 Wisconsin | #12 High Point | 10.5 | 8 | West Rd 1 (Portland), High Point +10.5 |
| 2:50 PM | CBS | #1 Duke | #16 Siena | 28.5 | 15 | East Rd 1 (Greenville), Siena +28.5 |
| 3:15 PM | TruTV | #5 Vanderbilt | #12 McNeese | 12.5 | 7 | South Rd 1 (Oklahoma City), McNeese +12.5 |
| 4:05 PM | TNT | #3 Michigan State | #14 North Dakota State | 15.5 | 9 | East Rd 1 (Buffalo), North Dakota St +15.5 |
| 4:25 PM | TBS | #4 Arkansas | #13 Hawaii | 14.5 | 11 | West Rd 1 (Portland), Hawaii +14.5 |
| 6:50 PM | TNT | #6 North Carolina | #11 VCU | 2.5 | -4 | South Rd 1 (Greenville), #ppiupsetalert, VCU +126 |
| 7:10 PM | CBS | #1 Michigan | #16 Howard | 31.5 | 22 | Midwest Rd 1 (Buffalo), Howard +31.5 |
| 7:25 PM | TBS | #6 BYU | #11 Texas | 2.5 | 0 | West Rd 1 (Portland), #ppiupsetalert, Texas +114 |
| 7:35 PM | TruTV | #7 Saint Mary’s | #10 Texas A&M | 2.5 | 4 | South Rd 1 (Oklahoma City), Saint Mary’s -2.5 |
| 9:25 PM | TNT | #3 Illinois | #14 Pennsylvania | 25.5 | 16 | South Rd 1 (Greenville), Pennsylvania +25.5 |
| 9:45 PM | CBS | #8 Georgia | #9 Saint Louis | 2.5 | -3 | Midwest Rd 1 (Buffalo), Saint Louis +116 |
| 10 PM | TBS | #3 Gonzaga | #14 Kennesaw State | 20.5 | 14 | West Rd 1 (Portland), Kennesaw St +20.5 |
| 10:10 PM | TruTV | #2 Houston | #15 Idaho | 23.5 | 18 | South Rd 1 (Oklahoma City), Idaho +23.5 |