#ppiupsetalert record: 39-59 (.398), #ncaavsspread: 19-25 (.432)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #2 Purdue | #7 Miami (FL) | 7.5 | 7 | West Rd 2 (St. Louis), Purdue -7.5 |
| 2:45 PM | CBS | #2 Iowa State | #7 Kentucky | 4.5 | 4 | Midwest Rd 2 (St. Louis), Kentucky +4.5 |
| 5:15 PM | CBS | #4 Kansas | #5 St. John’s | -3.5 | -5 | East Rd 2 (San Diego), #ppiupsetalert, St. John’s -166 |
| 6:10 PM | TNT | #3 Virginia | #6 Tennessee | -1.5 | 5 | Midwest Rd 2 (Philadelphia), Virginia -106 |
| 7:10 PM | TBS | #1 Florida | #9 Iowa | 10.5 | 6 | South Rd 2 (Tampa), Iowa +10.5 |
| 7:50 PM | TruTV | #1 Arizona | #9 Utah State | 11.5 | 7 | West Rd 2 (San Diego), Utah St +11.5 |
| 8:45 PM | TNT | #2 Connecticut | #7 UCLA | 4.5 | 6 | East Rd 2 (Philadelphia), UConn -4.5 |
| 7:50 PM | TruTV | #4 Alabama | #5 Texas Tech | -1.5 | 0 | Midwest Rd 2 (Tampa), Alabama -104 |