#ppiposseofpicks: 50-52 (.490)
#ppiupsetalert: 9-8 (.529)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | CBS | #2 Ohio State | #22 West Virginia | 6.5 | 6 | |
| 12 PM | BTN | #13 Maryland | Bryant University | 22.5 | 19 | |
| 12 PM | ESPNU | #20 Penn State | Cornell | 22.5 | 29 | #ppiposseofpicks: Penn State -22.5 |
| 2 PM | FS1 | #11 Michigan | UMass Lowell | 22.5 | 29 | #ppiposseofpicks: Michigan -22.5 |
| 3 PM | ABC | Stanford | #5 Kansas | -6.5 | 6 | #ppiupsetalert, #ppiposseofpicks: Stanford +210 |
| 4 PM | PAC12 | #6 Oregon | Alabama State | 30 | 30 | |
| 4 PM | SECN | #8 Auburn | Lipscomb | 20.5 | 24 | |
| 4 PM | ESPN2 | #16 Virginia | Navy | 18 | 13 | |
| 4 PM | #23 Texas Tech | CSU Bakersfield | 20 | 15 | ||
| 4 PM | ESPNU | #25 Iowa | Kennesaw State | 29.5 | 31 | |
| 8 PM | BTN | #14 Michigan State | Western Michigan | 27 | 21 | #ppiposseofpicks: Western Michigan +27 |
| 2:30 PM | Marshall | Duquesne | -7 | -9 | ||
| 4:30 PM | Middle Tennessee | Rhode Island | -6.5 | -9 | ||
| 5 PM | VCU | Loyola (MD) | 16 | 13 | ||
| 6:30 PM | SECN | Alabama | Richmond | 6.5 | 3 | |
| 7 PM | ESPN+ | Saint Louis | Bethune-Cookman | 14.5 | 23 | #ppiposseofpicks: Saint Louis -14.5 |
| 12 PM | ACCNX | Notre Dame | Alabama A&M | 25.5 | 16 | #ppiposseofpicks: Alabama A&M +25.5 |
| 4 PM | ACCN | NC State | Appalachian State | 13.5 | 11 | |
| 6 PM | ACCNX | Virginia Tech | Maryland-Eastern Shore | 29 | 27 | |
| 1 PM | ESPN3 | Connecticut | NJIT | 18 | 21 | |
| 3 PM | ESPN3 | Wichita State | Abilene Christian | 20.5 | 19 | |
| 5 PM | ESPN3 | South Florida | Florida Atlantic | 8.5 | 7 | |
| 6 PM | ESPN+ | Kansas State | Tulsa | 7 | 1 | #ppiposseofpicks: Tulsa +250 |
| 2:30 PM | ESPN+ | Oklahoma State | SE Louisiana | 24.5 | 25 | |
| 2 PM | ESPNU | Illinois | North Carolina A&T | 24.5 | 21 | |
| 2 PM | BTN | Nebraska | Texas A&M-CC | 12.5 | 8 | #ppiposseofpicks: Texas A&M-CC +12.5 |
| 4 PM | BTN | Northwestern | Hartford | 17 | 15 | |
| 6 PM | BTN | Indiana | Arkansas | 5 | 3 | |
| 2 PM | PAC12 | Colorado | Iona | 16.5 | 25 | #ppiposseofpicks: Colorado -16.5 |
| 6 PM | PAC12 | California | Harvard | -3.5 | 2 | #ppiposseofpicks: California +135 |
| 6 PM | Oregon State | North Dakota | 13.5 | 12 | ||
| 8 PM | PAC12 | Washington State | Arkansas-Pine Bluff | 22 | 14 | #ppiposseofpicks: Arkansas-Pine Bluff +22 |
| 10 PM | PAC12 | USC | Florida Gulf Coast | 22.5 | 33 | #ppiposseofpicks: USC -22.5 |
| 1:30 PM | SECN | LSU | Liberty | 6.5 | -1 | #ppiposseofpicks: Liberty +240 |
| 4 PM | SECN+ | Ole Miss | Tennessee Tech | 21.5 | 18 | |
| 6 PM | BTN | Indiana | Arkansas | 5 | 3 | |
| 6:30 PM | SECN | Alabama | Richmond | 6.5 | 3 |