#ppiposseofpicks: 101-128 (.441)
#ppiupsetalert: 27-33 (.450)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ACCNX | #6 Louisville | Georgia Tech | 13.5 | 13 | |
| 7 PM | CBSSN | #7 Dayton | St. Bonaventure | 15.5 | 15 | |
| 7 PM | ESPNU | #16 Auburn | South Carolina | 11 | 15 | |
| 8:30 PM | FS1 | #10 Seton Hall | Providence | 8.5 | 16 | Seton Hall -8.5 |
| 9 PM | BTN | #19 Iowa | #24 Rutgers | 5.5 | 6 | |
| 9 PM | ESPNU | Tulsa | #20 Memphis | -4 | 0 | #ppiupsetalert, Tulsa +155 |
| 7 PM | ESPN+ | Richmond | La Salle | 9 | 11 | |
| 7 PM | Davidson | Saint Louis | 3 | -5 | Saint Louis +135 | |
| 7 PM | ESPN+ | Rhode Island | Duquesne | 4 | 2 | |
| 7 PM | ESPN+ | Fordham | George Washington | -3 | 1 | |
| 7 PM | ESPN+ | George Mason | Massachusetts | 6.5 | 12 | George Mason -6.5 |
| 7 PM | ESPN2 | Notre Dame | Syracuse | 5 | 2 | |
| 8 PM | ACCN | Virginia Tech | North Carolina | 7 | 9 | |
| 9 PM | ACCNX | Pittsburgh | Boston College | 12 | 9 | |
| 7 PM | ESPNN | Temple | Cincinnati | -2.5 | 1 | |
| 8 PM | ESPN3 | SMU | East Carolina | 15 | 17 | |
| 6:30 PM | FS1 | Xavier | Georgetown | 5 | 3 | |
| 9 PM | CBSSN | DePaul | Creighton | 1 | 2 | |
| 7 PM | BTN | Michigan | Penn State | 5 | 3 | |
| 7 PM | SECN | Mississippi State | Arkansas | 4 | -1 | Arkansas +135 |
| 9 PM | SECN | Vanderbilt | Alabama | -9 | -8 |