#ppiposseofpicks: 113-144 (.440)
#ppiupsetalert: 32-39 (.464)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | St. John’s | #8 Villanova | -3 | -5 | #ppiupsetalert, St. John’s +3 |
| 7 PM | ESPN | Virginia | #5 Florida State | 1 | -3 | #ppiupsetalert, Virginia -110 |
| 8 PM | BTN | #25 Rutgers | Purdue | 0 | 3 | #ppiupsetalert, Purdue +135 |
| 9 PM | ESPN | #9 Duke | Pittsburgh | 16 | 13 | |
| 9 PM | CBSSN | Georgetown | #16 Butler | 1.5 | -3 | #ppiupsetalert, Georgetown -120 |
| 9 PM | ESPNU | Ole Miss | #17 Auburn | -5 | -7 | |
| 7 PM | CBSSN | VCU | Richmond | 9 | 5 | |
| 7 PM | George Mason | Rhode Island | -5 | -1 | ||
| 7 PM | ACCNX | Clemson | Syracuse | 2 | -2 | |
| 8 PM | ACCN | Miami (FL) | Virginia Tech | -3 | 1 | |
| 7 PM | ESPNN | Cincinnati | SMU | 5.5 | 3 | |
| 7 PM | ESPNU | Nebraska | Michigan | -5 | -7 | |
| 7 PM | ESPN+ | Bowling Green | Ball State | 1.5 | 7 | Bowling Green -1.5 |
| 6:30 PM | SECN | Tennessee | Texas A&M | 11.5 | 8 | |
| 7 PM | ESPN2 | Florida | Mississippi State | 6 | 5 | |
| 8:30 PM | SECN | Missouri | Georgia | 4.5 | 4 |