#ppiposseofpicks: 133-164 (.446)
#ppiupsetalert: 39-51 (.433)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | #10 Seton Hall | #23 Creighton | 6 | 8 | |
| 6:30 PM | CBSSN | #19 Butler | Xavier | 4.5 | 6 | |
| 7 PM | ESPN+ | #14 West Virginia | #3 Kansas | 1.5 | -1 | #ppiupsetalert, WVU -136 |
| 7 PM | ESPN2 | #11 Auburn | Alabama | 6.5 | 9 | |
| 8 PM | ACCN | Georgia Tech | #5 Louisville | -6 | -8 | |
| 8:30 PM | FS1 | #15 Villanova | #18 Marquette | 5 | 5 | Marquette +5 |
| 9 PM | ESPNU | South Florida | #20 Houston | -5.5 | -5 | |
| 7 PM | ESPNU | VCU | George Mason | 14 | 12 | |
| 7 PM | ESPN+ | La Salle | Richmond | -4.5 | -3 | |
| 7 PM | ACCNX | Miami (FL) | Boston College | 3.5 | 4 | |
| 9 PM | ACCNX | Pittsburgh | Clemson | 3 | 7 | |
| 7 PM | ESPNN | SMU | Connecticut | 5 | 6 | |
| 8 PM | ESPN3 | Tulane | Temple | -3 | -1 | |
| 8 PM | ESPN3 | Tulsa | East Carolina | 11.5 | 12 | |
| 9 PM | ESPN2 | Oklahoma | Iowa State | 10 | 9 | |
| 8:30 PM | CBSSN | St. John’s | Providence | -2 | 1 | |
| 7 PM | BTN | Ohio State | Rutgers | 6 | 5 | |
| 9 PM | BTN | Northwestern | Michigan | -6.5 | -6 | |
| 6:30 PM | SECN | Georgia | South Carolina | 2.5 | 2 | |
| 8:30 PM | SECN | Texas A&M | Florida | -5.5 | 0 | Texas A&M +210 |