#ppiposseofpicks: 151-177 (.460)
#ppiupsetalert: 45-57 (.441)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | #16 Seton Hall | #21 Butler | 5 | 7 | |
| 7 PM | ESPN | #11 Louisville | Syracuse | 10 | 11 | |
| 7 PM | ESPN2 | Georgia | #13 Auburn | -4 | -8 | Auburn -4 |
| 9 PM | ESPN | NC State | #6 Duke | -6.5 | -6 | |
| 9 PM | CBSSN | DePaul | #12 Villanova | -5 | -6 | |
| 9 PM | ESPNU | #22 Houston | Tulsa | 11 | 10 | |
| 7 PM | ESPN+ | Richmond | George Mason | 12 | 12 | |
| 8 PM | ESPN+ | Duquesne | George Washington | 10 | 12 | |
| 8 PM | ESPN+ | La Salle | Fordham | 8.5 | 9 | |
| 7 PM | ACCNX | Wake Forest | Georgia Tech | 1.5 | 1 | |
| 8 PM | ACCN | Virginia | Boston College | 11 | 9 | |
| 9 PM | ACCNX | Virginia Tech | Miami (FL) | 3.5 | 3 | |
| 7 PM | ESPNU | Cincinnati | UCF | 11 | 11 | |
| 7 PM | CBSSN | Memphis | East Carolina | 13 | 14 | |
| 8 PM | ESPN3 | Tulane | SMU | -8 | -7 | |
| 8 PM | LHN | Texas | TCU | 1.5 | 3 | |
| 9 PM | ESPN2 | Texas Tech | Kansas State | 11.5 | 12 | |
| 8:30 PM | FS1 | Georgetown | Providence | 1 | 6 | Georgetown -1 |
| 7 PM | BTN | Rutgers | Michigan | 1.5 | 3 | |
| 9 PM | BTN | Minnesota | Indiana | 5.5 | 4 | |
| 10 PM | PAC12 | Washington State | California | 5.5 | 5 | |
| 7 PM | SECN | Alabama | Texas A&M | 10.5 | 10 | |
| 9 PM | SECN | Mississippi State | South Carolina | 5.5 | 6 |