#ppiupsetalert record: 1-0 (100%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 2 PM | ESPN+ | #9 West Virginia | Northeastern | 18 | 22 | West Virginia -18 |
| 4 PM | ESPN+ | #2 Baylor | Central Arkansas | 34 | 19 | Central Arkansas +34 |
| 6 PM | ACCN | #24 Virginia Tech | Miami (FL) | 6 | 12 | Virginia Tech -6 |
| 7 PM | ESPN+ | #13 Texas Tech | Incarnate Word | 34.5 | 17 | Texas Tech +34.5 |
| 7 PM | FS1 | #14 Rutgers | Purdue | 3 | 0 | #ppiupsetalert, Purdue +135 |
| 7 PM | ACCNX | Clemson | #18 Florida State | 1.5 | 5 | Clemson +105, #ppiupsetalert |
| 9 PM | #1 Gonzaga | Dixie State | 37.5 | 22 | Dixie State +37.5 | |
| 9 PM | ESPN2 | Tulsa | #5 Houston | -8 | -12 | Houston -8 |
| 9 PM | FS1 | #10 Iowa | #19 Northwestern | 10.5 | 6 | Northwestern +10.5 |
| 8 PM | ESPN+ | Kansas State | Omaha | 10.5 | 2 | Omaha +450 |
| 7 PM | SECN | LSU | Texas A&M | 6.5 | 3 | Texas A&M +6.5 |
| 9 PM | SECN | Alabama | Ole Miss | 1 | 7 | Alabama -1 |