#ppiupsetalert record: 3-12 (.200)
| Time | Chan | Home | Away | Spread | Margin | |
| 7 PM | ESPNU | #18 Texas Tech | Kansas State | 16 | 15 | |
| 7 PM | ACCN | #19 Clemson | NC State | 5 | 13 | Clemson -5 |
| 8 PM | LHN | #4 Texas | Iowa State | 12 | 23 | Texas -12 |
| 9 PM | SECN | Mississippi State | #13 Missouri | -2 | -7 | Missouri -2 |
| 9 PM | ESPN2 | #23 Michigan State | #15 Rutgers | 1.5 | -4 | #ppiupsetalert, Rutgers +105 |
| 10 PM | ESPN | TCU | #6 Kansas | -5.5 | 3 | #ppiupsetalert, TCU +205 |
| 8 PM | ESPN | Miami (FL) | North Carolina | -2.5 | -6 | North Carolina -2.5 |
| 9 PM | FS1 | Marquette | Connecticut | 1 | 6 | Marquette -1 |
| 7 PM | SECN | Kentucky | Vanderbilt | 11.5 | 3 | Vanderbilt +11.5 |
| 7 PM | ESPN2 | Alabama | Florida | 2.5 | 9 | Alabama -2.5 |