#ppiupsetalert record: 23-28 (.451)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | BTN | Maryland | #24 Purdue | 2.5 | -3 | #ppiupsetalert, Maryland +125 |
| 7 PM | ESPN | #6 Texas | #2 Baylor | -5 | -5 | |
| 7 PM | #8 Iowa | Michigan State | 9.5 | 15 | Iowa -9.5 | |
| 7 PM | ESPN2 | Ole Miss | #11 Tennessee | -4 | -5 | #ppiupsetalert, Ole Miss +4 |
| 7 PM | ESPN+ | Iowa State | #17 West Virginia | -11.5 | -11 | |
| 8 PM | ESPN+ | #23 Kansas | Kansas State | 18 | 19 | |
| 8:30 PM | BTN | #19 Wisconsin | Penn State | 8.5 | 11 | |
| 9 PM | ESPN | Indiana | #12 Illinois | -2 | 0 | Indiana +115 |
| 6 PM | ESPN+ | Ball State | Buffalo | -4.5 | 3 | Ball State +170 |
| 5 PM | FS1 | Marquette | Butler | 4 | 6 | |
| 5 PM | ACCN | Notre Dame | Wake Forest | 5 | 9 | Notre Dame -5 |
| 7 PM | ACCN | Clemson | North Carolina | -2.5 | 1 | Clemson +125 |
| 7 PM | SECN | Auburn | Georgia | 8.5 | 8 | |
| 9 PM | FS1 | Stanford | USC | -2 | -1 | |
| 9 PM | SECN | Arkansas | Mississippi State | 7 | 11 | Arkansas -7 |