#ppiupsetalert record: 25-28 (.472)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6 PM | ESPN+ | East Carolina | #5 Houston | -16.5 | -16 | |
| 6:30 PM | SECN | #22 Florida | South Carolina | 8.5 | 13 | Florida -8.5 |
| 7 PM | ESPNU | #10 Alabama | LSU | 8.5 | 14 | Alabama -8.5 |
| 7 PM | ACCNX | Pittsburgh | #16 Virginia Tech | -3 | -2 | #ppiupsetalert, Pittsburgh +3 |
| 7 PM | ESPN2 | #18 Missouri | Kentucky | 4.5 | 14 | Missouri -4.5 |
| 9 PM | CBSSN | St. John’s | #3 Villanova | -9 | -1 | #ppiupsetalert, St. John’s +353 |
| 9 PM | ACCN | NC State | #14 Virginia | -7.5 | -7 | |
| 9 PM | FS1 | #15 Creighton | Georgetown | 13.5 | 19 | Creighton -13.5 |
| 7 PM | FS1 | Providence | Seton Hall | 1 | 1 | |
| 7 PM | ACCN | Syracuse | Louisville | 2.5 | 2 | |
| 9 PM | ESPN2 | TCU | Oklahoma State | -5 | -2 | TCU +5 |