#ppiupsetalert record: 28-28 (.500)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN2 | #9 Oklahoma | Iowa State | 14.5 | 17 | |
| 12 PM | ESPN | #18 Missouri | #10 Alabama | 2.5 | -2 | #ppiupsetalert, Missouri -145 |
| 12 PM | ACCNX | Miami (FL) | #16 Virginia Tech | -4 | -7 | |
| 2 PM | CBS | #17 West Virginia | #23 Kansas | 2.5 | 5 | |
| 2 PM | Valparaiso | #25 Drake | -12.5 | -18 | ||
| 2:30 PM | #12 Illinois | #19 Wisconsin | 4 | 4 | #ppiupsetalert, Wisconsin +4 | |
| 3 PM | ABC | Oklahoma State | #6 Texas | -2.5 | 3 | #ppiupsetalert, Oklahoma State +125 |
| 4 PM | ESPN+ | Kansas State | #13 Texas Tech | -16 | -11 | Kansas State +16 |
| 4 PM | ESPN | #14 Virginia | Pittsburgh | 10 | 12 | |
| 4:30 PM | #24 Purdue | Northwestern | 7 | 16 | Purdue -7 | |
| 5 PM | Marquette | #15 Creighton | -4.5 | -4 | #ppiupsetalert, Marquette +4 | |
| 8 PM | ESPN | Kentucky | #11 Tennessee | -4 | -3 | #ppiupsetalert, Kentucky +4 |
| 10 PM | ESPN | USC | #21 UCLA | 3.5 | 7 | USC -3.5 |
| 12 PM | FOX | Connecticut | Seton Hall | -1.5 | -1 | |
| 12 PM | CBSSN | Ball State | Toledo | -8.5 | -11 | |
| 2 PM | Weber State | Montana State | 5.5 | 6 | ||
| 12 PM | Butler | DePaul | 6.5 | 5 | ||
| 12 PM | ACCN | Boston College | NC State | -4 | 2 | Boston College +170 |
| 1 PM | SECN | Georgia | Vanderbilt | 5.5 | 10 | Georgia -5.5 |
| 2 PM | FS1 | Providence | St. John’s | 1 | -1 | |
| 2 PM | ACCN | Clemson | Syracuse | 3.5 | 7 | Clemson -3.5 |
| 3:30 PM | SECN | South Carolina | Mississippi State | 2.5 | 3 | |
| 4 PM | CBS | Oregon | Washington | 13 | 6 | Washington +13 |
| 4 PM | ESPN2 | Auburn | Ole Miss | 4 | 7 | |
| 6 PM | Oregon State | Washington State | 2.5 | 3 | ||
| 6 PM | ESPN | Duke | North Carolina | 3.5 | -2 | North Carolina +145 |
| 6:30 PM | BTN | Michigan State | Nebraska | 11.5 | 8 | Nebraska +11.5 |
| 8 PM | FS1 | Colorado | Arizona | 5 | 9 | Colorado -5 |
| 8 PM | ACCN | Georgia Tech | Notre Dame | 4.5 | 4 |