#ppiupsetalert record: 31-33 (.500)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | SECN | South Carolina | #11 Alabama | -7 | -13 | Alabama -7 |
| 8 PM | ESPN+ | Kansas State | #13 Texas | -14.5 | -11 | Kansas State +14.5 |
| 9 PM | ESPN | #7 Texas Tech | #14 West Virginia | 6 | 1 | #ppiupsetalert, West Virginia +5 |
| 9 PM | CBSSN | Georgetown | #19 Creighton | -7.5 | -8 | |
| 4:30 PM | ACCN | Duke | Notre Dame | 7 | 3 | Notre Dame +7 |
| 6:30 PM | ACCN | NC State | Syracuse | 2 | 0 | |
| 7 PM | ESPN2 | Michigan State | Penn State | 3 | 2 | |
| 7 PM | ESPN | Kentucky | Arkansas | 2 | -5 | Arkansas +2 |
| 8:30 PM | SECN | Vanderbilt | Auburn | -5 | -3 | |
| 9 PM | FS1 | Butler | St. John’s | 2 | -7 | St. John’s +2 |
| 9 PM | ESPNU | TCU | Iowa State | 6 | 13 | TCU -6 |