#ppiupsetalert record: 33-34 (.493)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN | #4 Ohio State | Indiana | 7 | 11 | Ohio State -7 |
| 12 PM | ACCNX | #17 Florida State | Wake Forest | 13 | 14 | |
| 12 PM | ESPN2 | Drake | #22 Loyola (CHI) | -4.5 | 5 | #ppiupsetalert, Drake +170 |
| 12 PM | ESPNU | #23 Oklahoma State | Kansas State | 13.5 | 19 | Oklahoma State -13.5 |
| 1 PM | ESPN+ | #14 West Virginia | #12 Oklahoma | 2.5 | 9 | #ppiupsetalert, West Virginia -2.5 |
| 2 PM | LHN | #13 Texas | TCU | 12 | 8 | TCU +12 |
| 2 PM | ESPN2 | LSU | #16 Tennessee | -2.5 | 1 | #ppiupsetalert, LSU +125 |
| 2:30 PM | FOX | Michigan State | #15 Iowa | -5 | -6 | |
| 3:30 PM | SECN | #11 Alabama | Georgia | 13 | 19 | Alabama -13 |
| 4 PM | #10 Missouri | Arkansas | 3 | 6 | ||
| 5 PM | FOX | #19 Creighton | #5 Villanova | -3 | 3 | #ppiupsetalert, Creighton +140 |
| 5 PM | BTN | #25 Rutgers | Northwestern | 8 | 13 | |
| 6 PM | ESPN2 | San Francisco | #1 Gonzaga | -16.5 | -13 | San Francisco +16.5 |
| 6 PM | ESPN | #9 Virginia | North Carolina | 6 | 9 | Virginia -6 |
| 8 PM | ESPNU | Washington State | #20 USC | -8 | -7 | |
| 12 PM | ESPN | Xavier | Connecticut | 3 | 7 | Xavier -3 |
| 2:05 PM | Montana State | Eastern Washington | -3 | -1 | ||
| 1 PM | SECN | Mississippi State | Vanderbilt | 7.5 | 10 | |
| 1 PM | CBS | Kentucky | Auburn | 2 | -1 | |
| 1:30 PM | CBSSN | Georgetown | Butler | 1 | 3 | |
| 2 PM | ACCN | Syracuse | Boston College | 11.5 | 15 | Syracuse -11.5 |
| 3 PM | ABC | Iowa State | Kansas | -11 | -12 | |
| 4 PM | Arizona | Oregon | 2 | 4 | ||
| 4 PM | ESPN | NC State | Duke | -3 | 3 | NC State +140 |
| 6 PM | SECN | South Carolina | Ole Miss | -1.5 | -1 | |
| 7:30 PM | PAC12 | Washington | UCLA | -9.5 | -11 | |
| 8 PM | DePaul | Providence | -1.5 | -4 | ||
| 10 PM | PAC12 | Stanford | Utah | 5 | 7 | |
| 10 PM | ESPNU | California | Colorado | -10.5 | -14 | Colorado -3 |