#ppiupsetalert record: 51-43 (.542)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 5 PM | ESPN | #6 West Virginia | #3 Baylor | -4 | 3 | #ppiupsetalert, West Virginia +160 |
| 6:30 PM | SECN | South Carolina | #12 Arkansas | -6 | -8 | |
| 7 PM | ESPN | #2 Michigan | #4 Illinois | 6.5 | 7 | |
| 7 PM | ESPN+ | #8 Alabama | Auburn | 11 | 17 | Alabama -11 |
| 7 PM | ESPN+ | Iowa State | #15 Texas | -11.5 | -10 | |
| 7 PM | ESPN+ | #18 Texas Tech | TCU | 12.5 | 9 | TCU +12.5 |
| 9 PM | ESPN2 | #23 Purdue | #25 Wisconsin | 1.5 | 6 | Purdue -1.5 |
| 7 PM | ESPN3 | Eastern Michigan | Ball State | -9 | -2 | Eastern Michigan +270 |
| 5 PM | ESPN+ | Central Michigan | Toledo | -16 | -14 | #ToledoBubble |
| 6 PM | ACCN | Pittsburgh | Wake Forest | 5 | 9 | Pittsburgh -5 |
| 7 PM | FS1 | Georgetown | Xavier | -2.5 | -1 | #XavierBubble |
| 8 PM | BTN | Michigan State | Indiana | 3 | 3 | #MSUBubble, #IndianaBubble, #DoubleBubble |
| 8 PM | ACCN | Georgia Tech | Duke | 1.5 | 6 | #GTBubble, #DukeBubble, #DoubleBubble, Georgia Tech -1.5 |
| 8:30 PM | SECN | LSU | Vanderbilt | 14 | 12 | |
| 9 PM | ESPNU | South Florida | Memphis | -9 | -6 | South Florida +9 |
| 9 PM | ESPN | Ole Miss | Kentucky | 3 | 6 | #OleMissBubble, #KentuckyBubble, #DoubleBubble |