#ppiupsetalert record: 51-46 (.525)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN2 | Notre Dame | #11 Florida State | -7 | -5 | |
| 1 PM | CBSSN | #20 Loyola (CHI) | Indiana State | 10.5 | 13 | |
| 2 PM | ESPN2 | #6 West Virginia | #17 Oklahoma State | 7.5 | 7 | |
| 2 PM | CBS | Georgia | #8 Alabama | -8 | -10 | |
| 2 PM | ESPN | #23 Purdue | Indiana | 7 | 11 | Purdue -7, #IndianaBubble |
| 2:30 PM | FOX | Providence | #10 Villanova | -4.5 | -4 | |
| 4 PM | ESPN | #7 Ohio State | #4 Illinois | 2 | 0 | #ppiupsetalert, Ohio State -130 |
| 5 PM | FOX | #14 Creighton | Butler | 12.5 | 14 | |
| 4 PM | ESPN2 | Louisville | #21 Virginia | -2 | 0 | Louisville +110, #ppiupsetalert, #LouisvilleBubble |
| 5 PM | SECN | #12 Arkansas | Texas A&M | 15 | 20 | Arkansas -15 |
| 12 PM | CBS | Connecticut | Georgetown | 9.5 | 11 | |
| 12 PM | ESPN | Kentucky | South Carolina | 7.5 | 7 | |
| 12 PM | ESPN+ | Navy | Loyola (MD) | 5.5 | 14 | Navy -5.5, #NavyBubble |
| 12 PM | FOX | Minnesota | Rutgers | -3.5 | 1 | Minnesota +150, #RutgersBubble |
| 12 PM | ACCNX | Clemson | Pittsburgh | 8 | 11 | |
| 1 PM | ESPN+ | Colgate | Boston University | 13.5 | 10 | Boston University +13.5, #ColgateBubble |
| 1 PM | Auburn | Mississippi State | 1.5 | 3 | #MississippiStBubble | |
| 1 PM | Montana State | Sacramento State | 4 | 7 | ||
| 1 PM | Wichita State | South Florida | 11.5 | 12 | #WichitaStBubble | |
| 2 PM | FS1 | Utah | Arizona State | 3.5 | 5 | |
| 2 PM | ESPN+ | Marshall | Charlotte | 12.5 | 16 | Marshall -12.5, #MarshallBubble |
| 3 PM | SECN | Missouri | LSU | 2 | 6 | Missouri -2 |
| 4 PM | CBS | UCLA | USC | -2.5 | -1 | |
| 5 PM | ESPN+ | Kansas State | Iowa State | 4.5 | 7 | |
| 5 PM | Western Kentucky | Old Dominion | 7 | 5 | #WKUBubble | |
| 6 PM | ESPN | North Carolina | Duke | 2.5 | 8 | North Carolina -2.5, #DukeBubble |
| 6 PM | CBSSN | St. Bonaventure | Saint Louis | 2 | 7 | St. Bonaventure -2, #BonnieBubble, #STLBubble, #DoubleBubble |
| 7 PM | SECN | Ole Miss | Vanderbilt | 8.5 | 10 | #OleMissBubble |
| 7 PM | FS1 | St. John’s | Seton Hall | -1 | 4 | #StJohn’sBubble, #SetonHallBubble, #DoubleBubble, St. John’s +100 |
| 8 PM | ESPN2 | UC Santa Barbara | Cal Poly | 19.5 | 24 | UCSB -19.5, #UCSBBubble |
| 8 PM | ESPN2 | Belmont | Morehead State | 6.5 | 3 | Morehead State +3, #BelmontBubble |
| 9 PM | ESPNU | Saint Mary’s | Loyola Marymount | 4.5 | 1 | Loyola Marymount +160 |
| 9 PM | FS1 | Marquette | Xavier | 2 | 3 | #XavierBubble |
| 11 PM | FS1 | Fresno State | Utah State | -9 | -4 | Fresno State +9, #UtahStateBubble |