#ppiupsetalert record: 2-5 (28.6%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN2 | #2 Duke | Appalachian State | 21.5 | 17 | |
| 10 PM | PAC12 | Stanford | Dartmouth | 13 | 11 |
PPI Projections: December 16, 2021
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The PPI
#ppiupsetalert record: 2-5 (28.6%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN2 | #2 Duke | Appalachian State | 21.5 | 17 | |
| 10 PM | PAC12 | Stanford | Dartmouth | 13 | 11 |