#ppiupsetrecord: 13-23 (36.1%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 5 PM | FS1 | DePaul | #20 Seton Hall | -5.5 | -2 | #ppiupsetalert, DePaul +5.5 |
| 5 PM | ESPNU | Washington State | Stanford | 6.5 | 6 | |
| 7 PM | ESPN2 | #13 Wisconsin | #16 Ohio State | 3.5 | 9 | Wisconsin -3.5 |
| 7 PM | ESPN+ | #19 Texas Tech | Oklahoma State | 8 | 8 | |
| 7 PM | FS1 | Georgetown | Butler | 1.5 | 3 | |
| 9 PM | FS1 | Iowa | Indiana | 5 | 1 | Indiana +5 |
| 9:30 PM | ESPN | #3 UCLA | Oregon | 11 | 11 | |
| 11 PM | ESPN2 | #2 Gonzaga | BYU | 15 | -2 | #ppiupsetalert, BYU +15 |
| 11 PM | ESPNU | #5 USC | Oregon State | 14.5 | 24 | USC -14.5 |
| 11 PM | ESPN | #6 Arizona | Colorado | 16 | 11 | Arizona +16 |