#ppiupsetrecord: 16-28 (36.4%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 5 PM | ESPN2 | West Virginia | #5 Baylor | -6.5 | -1 | #ppiupsetalert, West Virginia +6.5 |
| 7 PM | FS1 | #25 Connecticut | Butler | 12.5 | 9 | Butler +9 |
| 7 PM | ESPN3 | Toledo | Ball State | 14.5 | 15 | |
| 7 PM | ESPN | Oklahoma | #7 Kansas | -3.5 | -2 | #ppiupsetalert, Oklahoma +3.5 |
| 7 PM | ACCN | Miami (FL) | North Carolina | -2.5 | 3 | Miami (FL) +118 |
| 7 PM | SECN | Arkansas | South Carolina | 10.5 | 7 | South Carolina +10.5 |
| 7 PM | ESPNU | Ole Miss | Missouri | 9.5 | 6 | |
| 7 PM | ESPN2 | Michigan | Maryland | 6 | 6 | |
| 8 PM | ESPN+ | #10 Houston | South Florida | 18.5 | 22 | Houston -18.5 |
| 8 PM | ESPN+ | Evansville | #22 Loyola (CHI) | -13 | -14 | |
| 8:30 PM | LHN | #23 Texas | Kansas State | 11 | 9 | |
| 9 PM | ESPN | Florida State | #6 Duke | -4.5 | 1 | #ppiupsetalert, Florida State +162 |
| 9 PM | BTN | Northwestern | #8 Wisconsin | -2 | -8 | Wisconsin -2 |
| 9 PM | ESPNU | #18 Texas Tech | #15 Iowa State | 7.5 | 2 | #ppiupsetalert, Iowa State +7.5 |
| 9 PM | SECN | Vanderbilt | #24 Tennessee | 6.5 | 0 | #ppiupsetalert, Vanderbilt +6.5 |
| 9 PM | ACCN | Syracuse | Clemson | 3.5 | 4 | |
| 9 PM | CBSSN | Boise State | Air Force | 18 | 15 | |
| 11 PM | CBSSN | Fresno State | Utah State | 3 | 7 | Fresno State -3 |