#ppiupsetrecord: 18-31 (36.7%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | SECN | Florida | Mississippi State | 6 | 3 | |
| 7 PM | ESPN2 | Alabama | #13 LSU | 4 | 0 | #ppiupsetalert, Alabama -172 |
| 7 PM | Creighton | St. John’s | 3.5 | 6 | ||
| 7 PM | ACCNX | Louisville | Boston College | 7 | 10 | |
| 7 PM | ACCN | NC State | Virginia Tech | -1 | 5 | NC State +102 |
| 7 PM | ESPNU | Georgia Tech | Wake Forest | -2.5 | -6 | Wake Forest -2.5 |
| 8 PM | CBSSN | #11 Villanova | Marquette | 12.5 | 10 | |
| 8 PM | ESPN+ | Oklahoma State | TCU | 5 | 2 | |
| 8:30 PM | SECN | Texas A&M | #12 Kentucky | -7.5 | 0 | #ppiupsetalert, Texas A&M +260 |
| 8:30 PM | BTN | Rutgers | Iowa | -3.5 | -2 | |
| 9 PM | ESPNU | #2 Auburn | Georgia | 22 | 32 | Auburn -22 |
| 9 PM | FS1 | DePaul | #20 Xavier | -5.5 | -4 | #ppiupsetalert, DePaul +5.5 |
| 9 PM | ACCN | Pittsburgh | Virginia | -3.5 | -3 | |
| 9 PM | Wyoming | San Jose State | 17.5 | 14 | San Jose State +17.5 | |
| 10 PM | CBSSN | Colorado State | New Mexico | 16 | 19 |