#ppiupsetrecord: 22-38 (36.7%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | SECN | Georgia | Alabama | -14.5 | -13 | |
| 7 PM | ESPN+ | Ball State | Miami (OH) | -2.5 | 0 | |
| 7 PM | ESPN2 | #9 Duke | Clemson | 12 | 12 | |
| 7 PM | ESPN | #24 Illinois | #10 Michigan State | 5 | 1 | #ppiupsetalert, Illinois -230 |
| 7 PM | FS1 | #14 Villanova | DePaul | 17 | 16 | |
| 8 PM | ESPN+ | #4 Baylor | Kansas State | 14 | 16 | |
| 8 PM | ACCN | Pittsburgh | Syracuse | -4.5 | -4 | |
| 8 PM | BTN | Rutgers | Maryland | 4 | 5 | |
| 8:30 PM | CBSSN | #20 Connecticut | Georgetown | 17 | 15 | |
| 8:30 PM | SECN | MIssouri | #1 Auburn | -13.5 | -15 | |
| 9 PM | ESPN | #12 Kentucky | Mississippi State | 9.5 | 8 | |
| 9 PM | ESPNU | TCU | Texas | -2.5 | 6 | TCU +115 |
| 9 PM | FS1 | Colorado State | Nevada | 8 | 12 | Colorado State -7.5 |
| 9 PM | New Mexico | Fresno State | -5 | -8 | ||
| 9 PM | Boise State | Wyoming | 5 | 9 | Boise State -5 | |
| 10 PM | PAC12 | Oregon | Colorado | 7.5 | 7 |