#ppiupsetalertrecord: 24-40 (37.5%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FS1 | Butler | Georgetown | 5.5 | 9 | |
| 12 PM | ESPN2 | TCU | #19 LSU | -3 | 1 | #ppiupsetalert, TCU +130 |
| 12 PM | ESPN | Louisville | #9 Duke | -6 | -5 | |
| 12 PM | ACCNX | Georgia Tech | Miami (FL) | -2.5 | -6 | |
| 12 PM | USA | #25 Davidson | La Salle | 15 | 20 | Davidson -5 |
| 12:30 PM | CBS | #10 Michigan State | Michigan | 3 | 9 | Michigan State -3 |
| 2 PM | ESPN2 | Arkansas | West Virginia | 8 | 6 | |
| 2 PM | ESPNU | #23 Iowa State | Missouri | 10 | 13 | |
| 2 PM | ESPN | #1 Auburn | Oklahoma | 9.5 | 15 | Auburn -9.5 |
| 2 PM | ACCN | North Carolina | NC State | 7.5 | 10 | |
| 2 PM | FS1 | Creighton | #21 Xavier | -1.5 | -2 | #ppiupsetalert, Creighton +104 |
| 2:30 PM | CBS | #3 Arizona | Arizona State | 21.5 | 20 | |
| 2:30 PM | FOX | Maryland | Indiana | -1.5 | -1 | |
| 3 PM | ABC | Florida State | Virginia Tech | 2.5 | 11 | Florida State -2.5 |
| 3:30 PM | ESPN3 | Ball State | Western Michigan | 9.5 | 14 | Ball State -9.5 |
| 4 PM | ESPN | Alabama | #4 Baylor | -3 | -4 | #ppiupsetalert, Alabama +3 |
| 4 PM | ESPNU | Ole Miss | Kansas State | -1 | 1 | |
| 4 PM | ESPN2 | Florida | Oklahoma State | 3 | 5 | |
| 4:30 PM | BTN | Northwestern | #24 Illinois | -3.5 | -6 | |
| 4:30 PM | FOX | #14 Villanova | St. John’s | 13 | 16 | |
| 5 PM | PAC12 | Washington | Utah | 1.5 | 8 | Washington -1.5 |
| 6 PM | ACCN | Notre Dame | Virginia | 3 | 5 | |
| 6 PM | ESPN2 | #13 Texas Tech | Mississippi State | 7.5 | 7 | |
| 6 PM | SECN | Vanderbilt | Georgia | 9 | 12 | |
| 6 PM | ESPN | #5 Kansas | #12 Kentucky | 5 | 9 | Kansas -5 |
| 6 PM | ESPN+ | Montana State | Idaho | 14.5 | 18 | Montana State -14.5 |
| 6:30 PM | FS1 | DePaul | #20 Connecticut | -8 | -2 | #ppiupsetalert, DePaul +8 |
| 6:30 PM | BTN | Nebraska | Rutgers | -2 | -2 | |
| 7 PM | PAC12 | #15 USC | California | 12.5 | 16 | |
| 8 PM | ESPN2 | UCF | #7 Houston | -6.5 | -4 | #ppiupsetalert, UCF +6.5 |
| 8 PM | ACCN | Syracuse | Wake Forest | 1.5 | -5 | Wake Forest +104 |
| 8 PM | ESPN | Texas | #18 Tennessee | 3.5 | 1 | #ppiupsetalert, Tennessee +3.5 |
| 8:30 PM | SECN | Texas A&M | South Carolina | 7 | 5 | |
| 9 PM | Gonzaga | Portland | 32 | 21 | Portland +32 | |
| 9:30 PM | PAC12 | #7 UCLA | Stanford | 11.5 | 11 | |
| 10 PM | PAC12 | Oregon | Oregon State | 12.5 | 19 | Oregon -12.5 |
| 10 PM | CBSSN | Nevada | Utah State | 1 | 2 |