#ppiupsetalertrecord: 28-44 (38.9%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FOX | #12 Villanova | #17 Connecticut | 5.5 | 10 | Villanova -5.5 |
| 12 PM | ESPN | Indiana | #18 Illinois | 1.5 | 1 | #ppiupsetalert, Indiana -122 |
| 12 PM | ACCNX | Florida State | Wake Forest | 3 | 0 | |
| 12 PM | ESPN2 | Oklahoma State | Oklahoma | 2.5 | 0 | |
| 12 PM | FS1 | Butler | St. John’s | -1.5 | 2 | Butler -102 |
| 1 PM | SECN | Georgia | #1 Auburn | -16.5 | -23 | Auburn -16.5 |
| 1 PM | CBS | South Carolina | #22 Tennessee | -6.5 | -2 | #ppiupsetalert, South Carolina +6.5 |
| 1 PM | BTN | Nebraska | Northwestern | -3.5 | -1 | |
| 2 PM | ACCNX | Georgia Tech | Clemson | -2 | 0 | |
| 2 PM | ESPN2 | Syracuse | Louisville | 6.5 | 8 | |
| 2 PM | LHN | #23 Texas | #20 Iowa State | 8.5 | 4 | #ppiupsetalert, Texas -410 |
| 2 PM | FS1 | #21 Xavier | DePaul | 12.5 | 13 | |
| 2 PM | ESPN | West Virginia | #14 Texas Tech | -5 | -1 | #ppiupsetalert, West Virginia +5 |
| 2:30 PM | FOX | #4 Purdue | Michigan | 8.5 | 14 | Purdue -8.5 |
| 3 PM | ACCN | NC State | Notre Dame | 1 | -2 | |
| 3:30 PM | SECN | Florida | Ole Miss | 8 | 9 | |
| 4 PM | PAC12 | California | Washington State | -8 | -5 | |
| 4 PM | ESPN2 | Texas A&M | Missouri | 9 | 8 | |
| 4 PM | FS1 | Rutgers | #13 Michigan State | -2 | -8 | Michigan State -2 |
| 4 PM | ESPN | #10 Kansas | #8 Baylor | 2.5 | 4 | #ppiupsetalert, Kansas -138 |
| 5 PM | FOX | #7 Arizona | #19 USC | 11 | 7 | USC +11 |
| 5 PM | ACCN | Virginia | Miami (FL) | 4 | -2 | Miami (FL) +152 |
| 6 PM | ESPN | North Carolina | #9 Duke | -3 | 1 | #ppiupsetalert, UNC +116 |
| 6 PM | BTN | #11 Wisconsin | Penn State | 8.5 | 13 | Wisconsin -8.5 |
| 6 PM | SECN | Vanderbilt | #25 LSU | -3.5 | -3 | |
| 6 PM | FS1 | Colorado | Oregon State | 9 | 17 | Colorado -9 |
| 6 PM | CBSSN | Utah State | UNLV | 8.5 | 7 | |
| 6 PM | Boise State | San Jose State | 21.5 | 22 | ||
| 7 PM | ACCN | Pittsburgh | Virginia Tech | -6.5 | -4 | |
| 8 PM | ESPN+ | Weber State | Montana State | 6 | 9 | |
| 8 PM | ESPN | Alabama | #5 Kentucky | -1 | -1 | #ppiupsetalert, Alabama -108 |
| 8 PM | ESPNU | TCU | Kansas State | 4.5 | 11 | TCU -4.5 |
| 8 PM | CBSSN | Air Force | New Mexico | 1 | 8 | Air Force -1 |
| 8:30 PM | FS1 | Utah | Oregon | -3.5 | -7 | Oregon -3.5 |
| 8:30 PM | SECN | Arkansas | Mississippi State | 5 | 7 | |
| 10 PM | ESPN | BYU | #2 Gonzaga | -13 | 0 | #ppiupsetalert, BYU +13 |
| 10 PM | ESPN2 | Arizona State | #3 UCLA | -11.5 | -10 |