| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FOX | Butler | #11 Villanova | -9 | -9 | |
| 12 PM | ESPN | #13 Tennessee | #14 Arkansas | 6 | 5 | #ppiupsetalert, Arkansas +6 |
| 12 PM | CBS | LSU | #25 Alabama | 3.5 | 3 | #ppiupsetalert, LSU -184 |
| 12 PM | ESPN+ | Longwood | South Carolina Upstate | 7 | 8 | Big South Semis (N) |
| 12 PM | ESPN+ | Chattanooga | The Citadel | 13.5 | 11 | Southern Conf QFs (N) |
| 12 PM | ESPN2 | Louisville | Virginia | -4.5 | -1 | |
| 12 PM | ACCNX | Georgia Tech | Boston College | 3.5 | 3 | |
| 12:30 PM | ESPN+ | Texas State | Louisiana Lafayette | 4 | 7 | Sun Belt QFs (N) |
| 12:30 PM | USA | Dayton | Davidson | 4 | 0 | Davidson +152 |
| 1 PM | SECN | #5 Auburn | South Carolina | 15 | 15 | |
| 1 PM | ESPNU | Syracuse | Miami (FL) | 1.5 | 0 | |
| 2 PM | CBS | Florida | #7 Kentucky | -5 | -3 | #ppiupsetalert, Florida +5 |
| 2 PM | ESPN | #8 Purdue | Indiana | 10 | 12 | |
| 2 PM | ESPN+ | Winthrop | Gardner-Webb | 5 | 4 | Big South Semis (N) |
| 2 PM | ACCNX | Clemson | Virginia Tech | -2.5 | -1 | |
| 2 PM | ESPN2 | Florida State | NC State | 7 | 9 | |
| 2 PM | ESPN+ | West Virginia | TCU | 2.5 | -2 | TCU +118 |
| 2:30 PM | ESPN+ | Wofford | VMI | 6 | 4 | Southern Conf QFs (N) |
| 2:30 PM | FOX | Creighton | Seton Hall | 2 | 4 | |
| 2:30 PM | ESPNN | Notre Dame | Pittsburgh | 12 | 14 | |
| 3 PM | ESPN+ | Oklahoma State | #13 Texas Tech | -2.5 | -3 | #ppiupsetalert, Oklahoma State +2.5 |
| 3 PM | ESPN+ | Troy | Arkansas-Little Rock | 9.5 | 9 | Sun Belt QFs (N) |
| 3 PM | Arizona State | Stanford | 6 | 6 | ||
| 3:30 PM | CBSSN | Northern Iowa | Loyola (CHI) | -5 | 2 | MVC Semis (N): Northern Iowa +160 |
| 3:30 PM | SECN | Missouri | Georgia | 7 | 10 | |
| 4 PM | ESPN | #6 Kansas | #21 Texas | 6 | 10 | Kansas -6 |
| 4 PM | CBS | Washington State | Oregon | 2 | 3 | |
| 4 PM | ESPN+ | Kansas State | Oklahoma | 2.5 | 2 | |
| 4 PM | ESPN2 | Saint Louis | VCU | 2.5 | 0 | |
| 4 PM | Wyoming | Fresno State | 4.5 | 7 | ||
| 5 PM | FOX | #18 Connecticut | DePaul | 10 | 11 | |
| 5 PM | Arizona | California | 22.5 | 24 | ||
| 5 PM | William & Mary | Northeastern | -7.5 | 0 | William & Mary +7.5 | |
| 6 PM | ESPN+ | Montana State | Northern Colorado | 6 | 9 | |
| 6 PM | ESPN2 | #3 Baylor | Iowa State | 13 | 13 | |
| 6 PM | ESPN | #4 Duke | North Carolina | 11.5 | 10 | |
| 6 PM | ESPN3 | Bryant University | Mount St. Mary’s | 6.5 | 11 | Northeast Semis: Bryant -7 |
| 6 PM | ESPN+ | Georgia State | Arkansas State | 4 | 0 | Sun Belt QFs (N): Arkansas State +4 |
| 6 PM | CBSSN | Missouri State | Drake | 2 | 5 | MVC Semis (N) |
| 6 PM | ESPN+ | Liberty | Bellarmine | 7 | 7 | Atlantic Sun Semis |
| 6 PM | ESPN+ | Furman | Mercer | 7 | 7 | Southern Conf QFs (N) |
| 6 PM | SECN | Ole Miss | Vanderbilt | 1.5 | 3 | |
| 7 PM | ESPN+ | South Dakota State | Omaha | 22 | 22 | Summit QFs (N) |
| 7 PM | ESPN+ | Jacksonville State | Jacksonville | 6 | 6 | Atlantic Sun Semis |
| 7 PM | FS1 | Xavier | Georgetown | 12.5 | 15 | |
| 7:30 PM | Washington | Oregon State | 9 | 17 | Washington -9 | |
| 8 PM | ESPN3 | Wagner | Long Island | 6 | 8 | Northeast Semis |
| 8:30 PM | ESPN2 | #22 Murray State | Morehead State | 7.5 | 8 | OVC FINALS |
| 8:30 PM | ESPN+ | Appalachian State | Georgia Southern | 5.5 | 5 | |
| 8:30 PM | ESPN+ | Samford | UNC Greensboro | -1 | 6 | Southern Conf QFs (N) |
| 8:30 PM | SECN | Texas A&M | Mississippi State | 2 | 4 | |
| 8:30 PM | CBSSN | Colorado State | Boise State | 3.5 | 3 | |
| 9 PM | FS1 | Marquette | St. John’s | 4 | 7 | |
| 9:30 PM | ESPN+ | North Dakota State | Denver | 8.5 | 9 | Summit QFs (N) |
| 9:30 PM | ESPNU | Utah | Colorado | 2 | -4 | Colorado +110 |
| 10 PM | ESPN | #17 UCLA | #16 USC | 8 | 6 | #ppiupsetalert, UCLA -360 |
| 10:30 PM | ESPN2 | San Francisco | BYU | 3 | 1 | |
| 10:30 PM | CBSSN | Nevada | San Diego State | -4 | -6 | |
| 11 PM | New Mexico | UNLV | -3 | -6 | ||
| 12:30 AM | ESPN2 | Santa Clara | Portland | 8.5 | 6 | West Coast QFs (N) |
PPI Projections: March 5, 2022
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