#ppiupsetalertrecord: 3-4 (42.9%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 1 PM | ESPN2 | #7 Texas | Stanford | 10.5 | 7 | |
| 5:30 PM | ESPN | USC | #19 Auburn | -1.5 | -3 | #ppiupsetalert, USC -108 |
| 6 PM | ESPN+ | #21 TCU | Mississippi Valley State | 32.5 | 21 | |
| 10 PM | ESPN2 | #11 Baylor | Washington State | 9.5 | 6 | |
| 12 PM | BTN | Penn State | Canisius | 18.5 | 18 | |
| 1 PM | ESPN+ | Iowa State | Western Michigan | 23 | 19 | |
| 3 PM | PAC12 | Oregon State | Green Bay | 16.5 | 20 | |
| 5 PM | PAC12 | Colorado | Northern Colorado | 15.5 | 8 | Northern Colorado +15.5 |
| 5 PM | Santa Clara | California | 10.5 | 25 | Santa Clara -10.5 | |
| 5 PM | ESPN+ | West Virginia | Buffalo | 18.5 | 15 | |
| 5:30 PM | ESPN2 | Georgia | Notre Dame | -2.5 | 3 | Georgia +128 |
| 7 PM | Arizona State | San Diego | 11.5 | 17 |