#ppiupsetalertrecord 21-17 (55.3%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPNU | #11 Kansas State | Oklahoma State | 5.5 | 12 | Kansas State -5.5 |
| 7 PM | ESPN | #18 Wisconsin | Michigan State | -0.5 | 3 | #ppiupsetalert, Michigan State -120 |
| 8 PM | ESPN+ | #14 Iowa State | Texas Tech | 5.5 | 9 | |
| 9 PM | ESPN2 | #2 Kansas | Oklahoma | 11.5 | 14 | |
| 9 PM | SECN | #5 Tennessee | Vanderbilt | 17.5 | 15 | |
| 9 PM | ESPN | #13 Virginia | North Carolina | 4.5 | 5 | |
| 9 PM | ESPNU | Ole Miss | #21 Auburn | -2.5 | -8 | Auburn -2.5 |
| 11 PM | CBSSN | #23 San Diego State | Nevada | 9.5 | 5 | #ppiupsetalert, Nevada +9.5 |
| 6:30 PM | FS1 | St. John’s | Butler | 3.5 | 5 | |
| 7 PM | ACCN | Notre Dame | Georgia Tech | 5.5 | 3 | |
| 7 PM | ESPN2 | Kentucky | South Carolina | 18.5 | 9 | South Carolina +18.5 |
| 7 PM | SECN | LSU | Florida | -1.5 | 10 | LSU -110 |
| 7 PM | ESPN+ | Ohio | Ball State | 1.5 | 2 | |
| 8:30 PM | FS1 | Georgetown | Seton Hall | -9.5 | -10 | |
| 9 PM | CBSSN | DePaul | Villanova | -6.5 | 5 | DePaul +220 |
| 9 PM | BTN | Nebraska | Illinois | -2.5 | 6 | Nebraska +125 |