#ppiupsetalertrecord 22-18 (55.0%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | #5 Tennessee | Kentucky | 11.5 | 13 | |
| 12 PM | ACCNX | NC State | #16 Miami (FL) | 3.5 | 0 | #ppiupsetalert, NC State -170 |
| 1 PM | CBS | Indiana | #18 Wisconsin | 4.5 | -1 | #ppiupsetalert, Indiana -172 |
| 2 PM | ESPN2 | #17 TCU | #11 Kansas State | 4.5 | -3 | #ppiupsetalert, TCU -192 |
| 2 PM | ESPNU | Vanderbilt | #15 Arkansas | -3.5 | -2 | #ppiupsetalert, Vanderbilt +130 |
| 2 PM | FS1 | Creighton | #19 Providence | 6.5 | 0 | #ppiupsetalert, Creighton -275 |
| 3:30 PM | SECN | Florida | #20 Missouri | 5.5 | 1 | #ppiupsetalert, Florida -250 |
| 4 PM | ESPN+ | #2 Kansas | #14 Iowa State | 7.5 | 14 | Kansas -7.5 |
| 4 PM | ESPN | #4 Alabama | LSU | 14.5 | 16 | |
| 4 PM | ESPN2 | Florida State | #13 Virginia | -10.5 | -14 | |
| 4 PM | #22 Charleston | Elon | 20.5 | 37 | Charleston -20.5 | |
| 5 PM | ACCN | Clemson | #24 Duke | 1.5 | 6 | #ppiupsetalert, Clemson -110 |
| 6 PM | ESPN | Oregon | #9 Arizona | -4.5 | -4 | #ppiupsetalert, Oregon +150 |
| 8 PM | FOX | #7 UCLA | Colorado | 11.5 | 15 | |
| 8 PM | ESPN | #10 Texas | Texas Tech | 8.5 | 11 | |
| 8:30 PM | SECN | #21 Auburn | Mississippi State | 8.5 | 11 | |
| 9 PM | CBSSN | #23 San Diego State | New Mexico | 8.5 | 4 | #ppiupsetalert, New Mexico +275 |
| 10 PM | ESPN2 | #8 Gonzaga | Portland | 17.5 | 21 | |
| 12 PM | ESPN2 | Oklahoma | West Virginia | 3.5 | 4 | |
| 12 PM | FS1 | DePaul | Seton Hall | -4.5 | 2 | DePaul +160 |
| 1 PM | SECN | Ole Miss | Georgia | 5.5 | 1 | Georgia +5.5 |
| 2 PM | ESPN | Louisville | North Carolina | -12.5 | -15 | |
| 2 PM | ESPN3 | Ball State | Miami (OH) | 10.5 | 13 | |
| 3 PM | ACCN | Georgia Tech | Pittsburgh | -3.5 | -3 | |
| 4 PM | PAC12 | Oregon State | Arizona State | -8.5 | -11 | |
| 6 PM | ESPN2 | Baylor | Oklahoma State | 7.5 | 6 | |
| 6 PM | PAC12 | Washington | California | 9.5 | 16 | Washington -9.5 |
| 6 PM | SECN | South Carolina | Texas A&M | -8.5 | -7 | |
| 6 PM | ESPN+ | Montana State | Weber State | 7.5 | 7 | |
| 7 PM | ACCN | Syracuse | Notre Dame | 5.5 | 11 | Syracuse -5.5 |
| 8 PM | PAC12 | Washington State | Stanford | 7.5 | 11 | |
| 8 PM | ESPN2 | Boston College | Wake Forest | -1.5 | -3 | |
| 10:30 PM | PAC12 | USC | Utah | 5.5 | 11 | USC -3.5 |