#ppiupsetalertrecord 31-18 (63.3%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPN+ | Tulane | #1 Houston | -10.5 | -7 | |
| 7 PM | ESPN | #13 Kansas State | #2 Kansas | -1.5 | -3 | #ppiupsetalert, Kansas State +110 |
| 7 PM | ESPN2 | Mississippi State | #9 Tennessee | -6.5 | -2 | #ppiupsetalert, Mississippi State +210 |
| 8 PM | ESPN+ | #12 Iowa State | #7 Texas | 2.5 | -1 | #ppiupsetalert, Iowa State -146 |
| 8:30 PM | SECN | Vanderbilt | #4 Alabama | -7.5 | -10 | |
| 9 PM | ACCNX | Wake Forest | #19 Clemson | 2.5 | 1 | #ppiupsetalert, Wake Forest -146 |
| 9 PM | ESPNU | Texas Tech | #21 Baylor | 1.5 | -2 | #ppiupsetalert, Texas Tech -128 |
| 7 PM | ESPN+ | Ball State | Western Michigan | 9.5 | 13 | |
| 6:30 PM | SECN | South Carolina | Ole Miss | -5.5 | 2 | South Carolina +225 |
| 7 PM | ACCN | Georgia Tech | NC State | -5.5 | -7 | |
| 7 PM | ESPNU | Notre Dame | Florida State | 5.5 | 8 | |
| 7 PM | ACCNX | North Carolina | Boston College | 14.5 | 15 | |
| 7 PM | FS1 | Butler | Creighton | -7.5 | -1 | Butler +7.5 |
| 8:30 PM | BTN | Wisconsin | Penn State | 3.5 | 2 | |
| 9 PM | ESPN | Kentucky | Georgia | 10.5 | 2 | Georgia +10.5 |