#ppiupsetalertrecord 41-28 (59.4%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPNU | Florida State | #20 Miami (FL) | -3.5 | -6 | |
| 8 PM | ESPN+ | #11 TCU | Oklahoma | 6.5 | 7 | |
| 9 PM | ESPNU | #12 Iowa State | #5 Kansas State | 5.5 | -5 | #ppiupsetalert, Iowa State -235 |
| 9 PM | LHN | #10 Texas | Oklahoma State | 8.5 | 9 | |
| 9 PM | ACCN | #24 Clemson | Georgia Tech | 10.5 | 14 | |
| 6:30 PM | BTN | Rutgers | Penn State | 6.5 | 2 | Penn State +6.5 |
| 7 PM | ESPN+ | Ball State | Buffalo | 5.5 | 7 | |
| 7 PM | ACCN | NC State | Notre Dame | 7.5 | 10 | |
| 7 PM | FS1 | Georgetown | DePaul | -2.5 | -2 | |
| 7 PM | ESPN | Illinois | Ohio State | 3.5 | 7 | |
| 7 PM | ESPN2 | Arkansas | LSU | 12.5 | 9 | |
| 7 PM | SECN | Ole Miss | Missouri | 1.5 | -1 | |
| 9 PM | ESPN | Syracuse | North Carolina | -4.5 | 1 | Syracuse +155 |
| 9 PM | SECN | Vanderbilt | Kentucky | -5.5 | 0 | Vanderbilt +5.5 |
| 9 PM | FS1 | Boise State | Fresno State | 12.5 | 21 | Boise State -12.5 |
| 10 PM | San Jose State | Air Force | 3.5 | 8 | San Jose State -3.5 | |
| 11 PM | CBSSN | UNLV | Wyoming | 5.5 | 14 | UNLV -5.5 |