#ppiupsetalertrecord 49-34 (59.0%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 8 PM | FS1 | DePaul | #24 Connecticut | -10 | -11 | |
| 7 PM | ESPNU | #23 Miami (FL) | Virginia Tech | 3.5 | 10 | Miami (FL) -3.5 |
| 7 PM | ACCN | Boston College | #20 Clemson | -4.5 | -6 | |
| 8 PM | ESPN+ | #8 Kansas | #7 Kansas State | 7.5 | 6 | #ppiupsetalert, Kansas -360 |
| 8:30 PM | SECN | #4 Alabama | Vanderbilt | 15.5 | 19 | |
| 9 PM | ESPNU | #15 TCU | West Virginia | 2.5 | 5 | #ppiupsetalert, West Virginia +118 |
| 9 PM | ESPN2 | Maryland | #21 Indiana | 2.5 | 3 | #ppiupsetalert, Maryland -154 |
| 11 PM | Nevada | #22 San Diego State | -2.5 | 0 | #ppiupsetalert, Nevada +128 | |
| 7 PM | ESPN+ | Bowling Green | Ball State | -1.5 | -2 | |
| 6:30 PM | SECN | South Carolina | Mississippi State | -9.5 | -3 | South Carolina +9.5 |
| 7 PM | ESPN | Duke | Wake Forest | 7.5 | 8 | |
| 7 PM | BTN | Illinois | Nebraska | 14.5 | 17 | |
| 7 PM | ESPN2 | Arkansas | Texas A&M | 3.5 | 3 | |
| 9 PM | Iowa | Northwestern | 6.5 | 1 | Northwestern +6.5 | |
| 9 PM | ESPN | Ole Miss | Kentucky | -7.5 | -6 | |
| 9 PM | Colorado State | UNLV | 3.5 | 0 | ||
| 9 PM | Air Force | Boise State | -8.5 | -9 | ||
| 10 PM | FS1 | Wyoming | Fresno State | 4.5 | 3 | |
| 7 PM | ESPN+ | Fordham | Saint Louis | -4.5 | 3 | Fordham +150 |