#ppiupsetalertrecord 63-44 (58.9%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPN2 | #10 Tennessee | #1 Alabama | 2.5 | -8 | Alabama +130 |
| 7 PM | ESPNU | Louisville | #7 Virginia | -16.5 | -18 | |
| 7 PM | CBSSN | #11 Marquette | #16 Xavier | 5.5 | 12 | Marquette -5.5 |
| 9 PM | BTN | Northwestern | #14 Indiana | -2.5 | 4 | #ppiupsetalert, Northwestern +112 |
| 9 PM | ESPNU | #19 Iowa State | #22 TCU | 3.5 | 11 | Iowa State -3.5 |
| 11 PM | CBSSN | Fresno State | #21 San Diego State | -8.5 | -16 | San Diego State -8.5 |
| 6:30 PM | SECN | Florida | Ole Miss | 9.5 | 8 | |
| 7 PM | ACCN | Georgia Tech | Virginia Tech | -8.5 | -3 | Georgia Tech +285 |
| 7 PM | ACCNX | Clemson | Florida State | 9.5 | 17 | Clemson -9.5 |
| 8:30 PM | SECN | Mississippi State | Kentucky | 2.5 | 4 | |
| 9 PM | ESPN2 | Texas A&M | Arkansas | 3.5 | 5 | |
| 10 PM | FS1 | Colorado State | Boise State | -2.5 | -10 | Boise State -2.5 |
| 11 PM | ESPNU | Washington | Oregon | -5.5 | -3 |