#ppiupsetalertrecord 66-46 (58.9%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 1 PM | CBS | #3 Purdue | Ohio State | 11.5 | 19 | Purdue -11.5 |
| 1 PM | ESPN | #23 NC State | North Carolina | 2.5 | 4 | #ppiupsetalert, North Carolina +112 |
| 3 PM | ESPN | #2 Houston | Memphis | 13.5 | 15 | |
| 3 PM | FS1 | Butler | Georgetown | 4.5 | 10 | Butler -4.5 |
| 5 PM | FS1 | Nebraska | Maryland | -4.5 | -2 | |
| 6:30 PM | BTN | Northwestern | Iowa | -1.5 | 4 | Northwestern +105 |
| 7 PM | FS1 | Washington State | Oregon | 1.5 | -1 | |
| 9 PM | FS1 | Boise State | UNLV | 7.5 | 18 | Boise State -7.5 |