#ppiupsetalertrecord 70-49 (58.8%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | CBS | St. John’s | #18 Connecticut | -7 | -8 | |
| 12 PM | FOX | Villanova | #19 Creighton | -2.5 | -2 | #ppiupsetalert, Villanova +118 |
| 12 PM | ESPNU | #23 Iowa State | Oklahoma | 6.5 | 8 | |
| 12 PM | ESPN2 | Texas Tech | #24 TCU | 1.5 | 1 | #ppiupsetalert, Texas Tech |
| 2 PM | ESPN2 | #2 Alabama | Arkansas | 8.5 | 13 | Alabama -7.5 |
| 2 PM | CBS | #7 Arizona | Arizona State | 11.5 | 11 | |
| 2 PM | ESPN | #9 Baylor | #8 Texas | 3.5 | 3 | |
| 2 PM | ESPNU | Oklahoma State | #14 Kansas State | 2.5 | -5 | Kansas State +128 |
| 3:30 PM | SECN | Mississippi State | #25 Texas A&M | 1.5 | -3 | #ppiupsetalert, Mississippi State -120 |
| 4 PM | ESPN | #3 Kansas | West Virginia | 9.5 | 13 | Kansas -9.5 |
| 6 PM | ESPN | North Carolina | #6 Virginia | 2.5 | 0 | #ppiupsetalert, North Carolina -154 |
| 6 PM | SECN | #11 Tennessee | South Carolina | 21.5 | 19 | |
| 7:30 PM | FOX | #5 Purdue | #17 Indiana | 7.5 | 13 | Purdue -7.5 |
| 7:30 PM | FS1 | #10 Marquette | DePaul | 14.5 | 21 | Marquette -14.5 |
| 8 PM | ESPN2 | East Carolina | #1 Houston | -21.5 | -13 | East Carolina +21.5 |
| 10 PM | ESPN | #12 Gonzaga | #15 Saint Mary’s | 5.5 | 4 | #ppiupsetalert, Saint Mary’s +190 |
| 10 PM | CBSSN | New Mexico | #22 San Diego State | -2.5 | -1 | #ppiupsetalert, New Mexico +118 |