#ppiupsetalertrecord 81-58 (58.3%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | BTN | #5 Purdue | Rutgers | 6.5 | 13 | Big Ten QF – Purdue -6.5 |
| 12:30 PM | CBSSN | Florida Atlantic | Middle Tennessee | 10.5 | 10 | C-USA Semis |
| 1 PM | ESPN2 | #1 Houston | East Carolina | 22.5 | 22 | AAC QF |
| 1 PM | ESPN | #4 Alabama | Mississippi State | 7.5 | 11 | SEC QF – Alabama -7.5 |
| 2:30 PM | BTN | Michigan State | Ohio State | 4.5 | 9 | Big Ten QF – Michigan State -4.5 |
| 3 PM | ESPN | #25 Missouri | #17 Tennessee | -5.5 | -4 | SEC QF |
| 3 PM | ESPN+ | Alabama A&M | Texas Southern | -2.5 | -1 | SWAC Semis |
| 3 PM | CBSSN | North Texas | UAB | 1.5 | 3 | C-USA Semis |
| 3 PM | ESPN2 | Cincinnati | Temple | 4.5 | 9 | AAC QF – Cincinnati -4.5 |
| 5 PM | CBSSN | Toledo | Ohio | 5.5 | 7 | MAC Semis |
| 6 PM | ESPN+ | Howard | Maryland-Eastern Shore | 2.5 | 1 | MEAC Semis |
| 6 PM | ESPN | Iona | Niagara | 13.5 | 10 | MAAC Semis – Niagara +13.5 |
| 6:30 PM | BTN | Northwestern | Penn State | 1.5 | 0 | Big Ten QF |
| 6:30 PM | FS1 | #11 Connecticut | #6 Marquette | 3.5 | 2 | Big East Semis – #ppiupsetalert Connecticut -176 |
| 7 PM | ESPN | #3 Kansas | Iowa State | 4.5 | 9 | Big 12 Semis – Kansas -4.5 |
| 7 PM | ESPN2 | #14 Miami (FL) | #21 Duke | -2.5 | -1 | ACC Semis – #ppiupsetalert, Duke -154 |
| 7 PM | SECN | #18 Texas A&M | Arkansas | 1.5 | 4 | SEC QF |
| 7 PM | ESPNU | Memphis | UCF | 5.5 | 3 | AAC Semis |
| 7:30 PM | CBSSN | Kent State | Akron | -2.5 | 2 | MAC Semis – Akron +108 |
| 8 PM | ESPN+ | North Carolina Central | Norfolk State | 0.5 | 0 | MEAC Semis |
| 8:30 PM | ESPNN | Saint Peter’s | Marist | 0.5 | 2 | MAAC Semis |
| 9 PM | PAC12 | #2 UCLA | Oregon | 5.5 | 5 | PAC 12 Semis |
| 9 PM | FS1 | #15 Xavier | #24 Creighton | -3.5 | -4 | Big East Semis – #ppiupsetalert Creighton -164 |
| 9 PM | BTN | #19 Indiana | Maryland | 2.5 | -3 | Big Ten QF – #ppiupsetalert, Maryland +115 |
| 9 PM | SECN | #23 Kentucky | Vanderbilt | 8.5 | 3 | SEC QF – Vanderbilt +8.5 |
| 9 PM | ESPNU | Tulane | Wichita State | 1.5 | 2 | AAC QF |
| 9 PM | ESPN+ | Sam Houston State | Grand Canyon | 2.5 | 6 | WAC Semis – Sam Houston St -2.5 |
| 9 PM | ESPN+ | UC Irvine | Cal State Fullerton | 2.5 | 5 | Big West Semis |
| 9:30 PM | ESPN | #7 Texas | #22 TCU | 2.5 | 1 | Big 12 Semis – #ppiupsetalert, TCU +116 |
| 9:30 PM | ESPN2 | #13 Virginia | Clemson | 2.5 | 0 | ACC Semis – #ppiupsetalert, Clemson +130 |
| 9:30 PM | CBSSN | #20 San Diego State | San Jose State | 8.5 | 9 | MW Semis |
| 9:30 PM | ESPN+ | Grambling State | Jackson State | 5.5 | 8 | SWAC Semis |
| 11 PM | ESPN+ | Utah Valley | Southern Utah | 3.5 | 5 | WAC Semis |
| 11:30 PM | ESPN | #8 Arizona | Arizona State | 7.5 | 8 | PAC 12 Semis |
| 11:30 PM | ESPNU | UC Santa Barbara | UC Riverside | 2.5 | -1 | Big West Semis – UC Riverside +128 |
| 11:59 PM | CBSSN | Boise State | Utah State | -2.5 | -1 | MW Semis |