#ppiupsetalertrecord: 2-3 (.400)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN2 | #19 Texas | LSU | 6.5 | 3 | #ppiupsetalert, LSU +240 (@ Houston, TX) |
| 12 PM | CW | #24 Miami (FL) | La Salle | 16.5 | 10 | La Salle +15.5 |
| 12:30 PM | CBS | Indiana | #2 Kansas | -7.5 | 2 | #ppiupsetalert, Indiana +235 |
| 2 PM | FOX | Michigan State | #6 Baylor | -2.5 | -7 | Baylor -2.5 |
| 2 PM | Hampton | #20 James Madison | -15.5 | -16 | ||
| 2:30 PM | ESPN2 | #4 Houston | Texas A&M | 7.5 | 6 | |
| 3 PM | ESPN+ | Memphis | #13 Clemson | 2.5 | 0 | #ppiupsetalert, Memphis -152 |
| 4 PM | ESPNU | St. Bonaventure | #15 Florida Atlantic | -9.5 | -11 | @ Springfield, MA |
| 4:30 PM | Peacock | #3 Purdue | #1 Arizona | -1.5 | 5 | #ppiupsetalert, Arizona -111 |
| 5:30 PM | CBS | #14 Kentucky | #9 North Carolina | -1.5 | -5 | North Carolina -1.5 (@ Atlanta, GA) |
| 5:30 PM | FS1 | DePaul | #25 Northwestern | -9.5 | -8 | |
| 6 PM | ACCN | #22 Virginia | Northeastern | 17.5 | 17 | |
| 8 PM | FOX | #8 Creighton | Alabama | 6.5 | 5 | |
| 9 PM | ESPN+ | #11 Oklahoma | Green Bay | 24.5 | 23 | |
| 9 PM | ESPN+ | #18 BYU | Georgia State | 24.5 | 26 | |
| 10 PM | ESPN2 | #12 Tennessee | NC State | 9.5 | 4 | @ San Antonio, TX |
| 12 PM | BTN | Penn State | Georgia Tech | 2.5 | -3 | Georgia Tech +116 |
| 12 PM | ESPN+ | IUPUI | Lindenwood | 1.5 | -5 | Lindenwood +102 |
| 1 PM | ESPN+ | Niagara | NJIT | 6.5 | 3 | NJIT +6.5 |
| 1 PM | Rutgers | Long Island | 26.5 | 17 | Long Island +26.5 | |
| 1:30 PM | FS1 | Providence | Sacred Heart | 20.5 | 24 | Providence -20.5 |
| 1:45 PM | Indiana State | Ball State | 13.5 | 10 | Ball State +13.5 (@ Indianapolis, IN) | |
| 2 PM | Le Moyne | Dartmouth | -3.5 | -2 | ||
| 2 PM | ESPN+ | Tulane | Southern University | 14.5 | 9 | Southern University +14.5 |
| 2 PM | ESPN+ | Mercer | Florida Gulf Coast | 1.5 | 1 | |
| 2 PM | Hofstra | Norfolk State | 9.5 | 3 | Norfolk State +9.5 | |
| 2 PM | ESPN+ | Presbyterian College | Kennesaw State | -2.5 | -1 | |
| 2 PM | Towson | Bryant University | 2.5 | 2 | @ Elmont, NY | |
| 2 PM | Monmouth | Rider | 5.5 | 15 | Monmouth -5.5 | |
| 2 PM | Drexel | Albany | 10.5 | 5 | Albany +10.5 | |
| 2 PM | ESPN+ | Bowling Green | Kansas City | 5.5 | 6 | |
| 2 PM | PAC12 | Washington State | Santa Clara | 5.5 | 2 | Santa Clara +5.5 (@ Phoenix, AZ) |
| 2 PM | ESPN+ | UIC | Western Michigan | 11.5 | 15 | UIC -11.5 |
| 2 PM | ACCN | Pittsburgh | South Carolina State | 26.5 | 22 | South Carolina State +26.5 |
| 2 PM | ESPN+ | VCU | Temple | 9.5 | 7 | |
| 2:30 PM | BTN | Michigan | Eastern Michigan | 23.5 | 15 | Eastern Michigan +23.5 |
| 3 PM | ESPN+ | Western Kentucky | Austin Peay | 9.5 | 11 | |
| 3 PM | ESPN+ | Georgia Southern | UNC Wilmington | -9.5 | -19 | UNC Wilmington -9.5 |
| 3 PM | ESPN+ | Northwestern State | Rice | -8.5 | -5 | Northwestern State +8.5 |
| 3 PM | CBS | UCLA | Ohio State | -1.5 | -4 | @ Atlanta, GA |
| 3 PM | ESPN+ | Tulsa | Missouri State | -1.5 | -5 | Missouri State -1.5 |
| 3 PM | ESPN+ | Samford | Belmont | 3.5 | 5 | |
| 3:30 PM | ESPN+ | Bucknell | Radford | -5.5 | -3 | |
| 3:30 PM | FS1 | St. John’s | Fordham | 14.5 | 13 | |
| 4 PM | Utah State | San Francisco | 2.5 | 14 | Utah State -2.5 | |
| 4 PM | ESPN+ | Valparaiso | Chicago State | 3.5 | 16 | Valparaiso -3.5 |
| 4 PM | ESPN+ | Murray State | SE Louisiana | 9.5 | 8 | |
| 4 PM | ESPN+ | Bellarmine | Evansville | 2.5 | -8 | Evansville +128 |
| 4 PM | ESPN+ | Tennessee Tech | North Alabama | -2.5 | -2 | |
| 4 PM | PAC12 | Utah | Utah Valley | 17.5 | 17 | |
| 4 PM | ESPN+ | Northern Arizona | Southern Utah | 4.5 | 12 | Northern Arizona -4.5 |
| 4 PM | ACCN | Virginia Tech | Vermont | 9.5 | 2 | Vermont +9.5 |
| 4 PM | Appalachian State | Gardner-Webb | 7.5 | 15 | Appalachian State -7.5 | |
| 4 PM | ESPN+ | South Florida | Loyola (CHI) | 1.5 | 1 | |
| 4:30 PM | BTN | Iowa | Florida A&M | 23.5 | 11 | Florida A&M +23.5 |
| 4:30 PM | ESPN+ | UC Santa Barbara | Loyola Marymount | -3.5 | -5 | @ Phoenix, AZ |
| 4:30 PM | Rhode Island | Delaware | -3.5 | -9 | Delaware -3.5 (@ Elmont, NY) | |
| 4:30 PM | ESPN+ | South Carolina State | Western Carolina | -4.5 | -11 | Western Carolina -4.5 |
| 5 PM | ESPN+ | UMass Lowell | Central Connecticut State | 11.5 | 14 | |
| 5 PM | ESPN+ | UT-Arlington | Air Force | 1.5 | 3 | |
| 5:30 PM | SECN | Georgia | High Point | 8.5 | 6 | |
| 6 PM | SECN | Arkansas | Lipscomb | 14.5 | 13 | |
| 6 PM | ESPN+ | South Carolina | Charleston Southern | 19.5 | 26 | South Carolina -19.5 |
| 6 PM | ESPN+ | George Mason | Loyola (MD) | 13.5 | 28 | George Mason -13.5 |
| 6:30 PM | ESPNU | Massachusetts | West Virginia | -2.5 | 9 | UMass +126 |
| 7 PM | ESPN+ | Saint Mary’s | UNLV | 5.5 | 6 | @ Phoenix, AZ |
| 7 PM | ESPN+ | Richmond | Charlotte | 4.5 | 1 | Charlotte +4.5 |
| 7 PM | ESPN+ | Marshall | UNC Greensboro | -1.5 | -6 | UNC Greensboro -1.5 |
| 7 PM | ESPN+ | Wichita State | Southern Illinois | 5.5 | 8 | |
| 7 PM | Saint Joseph’s | Iona | 7.5 | 14 | Saint Joseph’s -7.5 (@ Elmont, NY) | |
| 7 PM | ESPN+ | Cincinnati | Dayton | 4.5 | 3 | |
| 7 PM | ESPN+ | Purdue Fort Wayne | Bethune-Cookman | 13.5 | 18 | Purdue Fort Wayne -13.5 |
| 7:30 PM | SECN | Ole Miss | California | 3.5 | 16 | Ole Miss -3.5 (@ San Antonio, TX) |
| 7:30 PM | ESPN+ | Texas Tech | Vanderbilt | 7.5 | 16 | Texas Tech -7.5 (@ Fort Worth, TX) |
| 7:30 PM | FS1 | Xavier | Winthrop | 11.5 | 6 | Winthrop +11.5 |
| 8 PM | ESPN+ | UC Riverside | California Baptist | -2.5 | -1 | |
| 8 PM | Alabama A&M | Chattanooga | -9.5 | -5 | Alabama A&M +9.5 | |
| 8 PM | ACCN | Florida State | SMU | 4.5 | 2 | |
| 9 PM | Wyoming | Weber State | 1.5 | 5 | Wyoming -1.5 | |
| 9 PM | ESPN+ | Utah Tech | North Dakota | 4.5 | 7 | |
| 9:30 PM | Grand Canyon | Portland | 11.5 | 17 | Grand Canyon -11.5 | |
| 9:30 PM | ESPN+ | North Carolina A&T | Texas Southern | -9.5 | -17 | Texas Southern -9.5 (@ Las Vegas, NV) |
| 10 PM | ESPNU | TCU | Arizona State | 7.5 | -1 | Arizona State +270 (@ Fort Worth, TX) |
| 10 PM | ESPN+ | UC Irvine | South Dakota | 15.5 | 15 | |
| 11:59 PM | ESPNU | Howard | Jackson State | 3.5 | 1 | @ Las Vegas, NV |