#ppiupsetalertrecord: 4-6 (.400)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | CBSSN | Seton Hall | #5 Connecticut | -8.5 | -8 | |
| 7 PM | ESPN | #10 Baylor | #21 Duke | -2.5 | 4 | Baylor +122 (@ New York, NY) |
| 9 PM | ESPN | #7 Oklahoma | #11 North Carolina | -2.5 | 6 | Oklahoma +128 (@ Charlotte, NC) |
| 9 PM | FS1 | #12 Creighton | Villanova | 8.5 | 5 | Villanova +8.5 |
| 9 PM | ESPN+ | #15 Gonzaga | Jackson State | 25.5 | 19 | Jackson State +25.5 |
| 11 PM | ESPN | #4 Arizona | Alabama | 7.5 | 11 | Arizona -7.5 (@ Phoenix, AZ) |
| 3 PM | ESPN+ | Oklahoma State | Wofford | 13.5 | 5 | Wofford +13.5 |
| 5 PM | PAC12 | California | UC San Diego | 8.5 | 3 | UC San Diego +8.5 |
| 7 PM | FS1 | St. John’s | Xavier | 5.5 | 5 | |
| 7 PM | ESPN+ | Georgia | Mount St. Mary’s | 11.5 | 15 | Georgia -11.5 |
| 7 PM | ESPN+ | NC State | Saint Louis | 12.5 | 12 | |
| 7 PM | Wyoming | South Dakota State | -4.5 | 0 | Wyoming +160 | |
| 7 PM | ACCNX | Pittsburgh | Purdue Fort Wayne | 13.5 | 7 | Purdue Fort Wayne +13.5 |
| 7 PM | ESPN+ | West Virginia | Radford | 6.5 | -7 | Radford +230 |
| 7:30 PM | Nebraska | North Dakota | 18.5 | 16 | ||
| 8 PM | BTN | Iowa | UMBC | 26.5 | 22 | UMBC +26.5 |
| 8:30 PM | ESPN2 | Arizona State | Northwestern | -3.5 | 6 | Arizona State +146 (@ Phoenix, AZ) |
| 9 PM | New Mexico | UC Irvine | 9.5 | 4 | UC Irvine +9.5 | |
| 9 PM | PAC12 | Utah | Bellarmine | 20.5 | 29 | Utah -20.5 |