#ppiupsetalertrecord: 7-10 (.412)
#ppiupsetalertrecord: 7-10 (.412)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPN2 | Iowa State | #2 Houston | -2.5 | 0 | #ppiupsetalert, Iowa State +114 |
| 7 PM | ESPN | #6 Kentucky | Missouri | 12.5 | 15 | |
| 7 PM | ESPN+ | Cincinnati | #25 Texas | 4.5 | 6 | #ppiupsetalert, Cincinnati -200 |
| 9 PM | Peacock | Nebraska | #1 Purdue | -7.5 | -9 | |
| 9 PM | ESPN | Pittsburgh | #12 Duke | -5.5 | -2 | #ppiupsetalert, Pittsburgh +176 |
| 9 PM | ESPN+ | #14 Baylor | #18 BYU | 3.5 | 1 | #ppiupsetalert, BYU +150 |
| 9 PM | ESPN2 | #16 Auburn | Texas A&M | 7.5 | 13 | Auburn -7.5 |
| 9 PM | Boise State | #17 Colorado State | -2.5 | -7 | Colorado State -2.5 | |
| 9 PM | #20 Utah State | Wyoming | 15.5 | 16 | ||
| 9 PM | CBSSN | DePaul | #22 Creighton | -15.5 | -16 | |
| 11 PM | CBSSN | San Jose State | #19 San Diego State | -10.5 | -13 | |
| 6:30 PM | FS1 | Georgetown | Seton Hall | -7.5 | -6 | |
| 7 PM | ACCN | Florida State | Wake Forest | -3.5 | -2 | |
| 7 PM | ESPN+ | West Virginia | Kansas State | -2.5 | -14 | Kansas State -2.5 |
| 7 PM | Peacock | Rutgers | Indiana | 3.5 | -3 | Indiana +130 |
| 7 PM | SECN | Alabama | South Carolina | 11.5 | 1 | South Carolina +11.5 |
| 7 PM | ESPN+ | Ball State | Akron | -7.5 | -9 | |
| 8 PM | ESPN+ | Texas Tech | Oklahoma State | 8.5 | 15 | Texas Tech -8.5 |
| 9 PM | ACCN | Georgia Tech | Notre Dame | 6.5 | 10 | Georgia Tech -6.5 |
| 9 PM | SECN | LSU | Vanderbilt | 7.5 | 15 | LSU -7.5 |