#ppiupsetalertrecord: 8-13 (.381)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPN+ | UCF | #3 Kansas | -7.5 | -4 | #ppiupsetalert, UCF +245 |
| 7 PM | SECN | Mississippi State | #5 Tennessee | -2.5 | 0 | #ppiupsetalert, Mississippi State +112 |
| 7 PM | ESPN2 | Virginia Tech | #21 Clemson | -1.5 | -3 | #ppiupsetalert, Virginia Tech +114 |
| 8 PM | ESPN | NC State | #7 North Carolina | -2.5 | -3 | #ppiupstealert, NC State +126 |
| 8 PM | ESPN+ | #13 Memphis | UTSA | 19.5 | 32 | Memphis -19.5 |
| 8:30 PM | FS1 | Xavier | #4 Connecticut | -4.5 | -1 | #ppiupstealert, Xavier +168 |
| 8:30 PM | BTN | Ohio State | #15 Wisconsin | 2.5 | 0 | #ppiupsetalert, Ohio State -154 |
| 9 PM | CBSSN | #11 Marquette | Butler | 11.5 | 10 | |
| 6:30 PM | BTN | Penn State | Northwestern | 1.5 | -4 | Northwestern -106 |
| 6:30 PM | FS1 | St. John’s | Providence | 9.5 | 12 | |
| 7 PM | ACCN | Miami (FL) | Louisville | 16.5 | 16 | |
| 9 PM | ACCN | Syracuse | Boston College | 4.5 | 8 | Syracuse -4.5 |
| 9 PM | ESPNU | Georgia | Arkansas | 1.5 | 3 | |
| 9 PM | SECN | Ole Miss | Florida | -2.5 | 10 | Ole Miss +112 |
| 10:30 PM | FS1 | USC | Washington State | 6.5 | 7 | |
| 11 PM | ESPNU | California | Colorado | -4.5 | -5 |