#ppiupsetalertrecord: 16-21 (.432)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 5 PM | ESPN2 | #6 Tennessee | Florida | 9.5 | 11 | |
| 7 PM | Peacock | Indiana | #2 Purdue | -9.5 | -7 | |
| 7 PM | ESPN+ | Cincinnati | #19 TCU | 2.5 | 1 | #ppiupsetalert, Cincinnati -140 |
| 8 PM | ESPN+ | Kansas State | #9 Baylor | -1.5 | 1 | #ppiupsetalert, Kansas State -105 |
| 8 PM | CBSSN | #21 Dayton | Saint Louis | 13.5 | 21 | Dayton -13.5 |
| 9 PM | ESPN | Oklahoma State | #3 Kansas | -6.5 | -11 | Kansas -6.5 |
| 9 PM | BTN | Penn State | #11 Wisconsin | -5.5 | -14 | Wisconsin -5.5 |
| 9 PM | ESPN+ | #20 BYU | #24 Iowa State | 4.5 | 7 | |
| 10:30 PM | FS1 | New Mexico | #16 Utah State | 5.5 | 1 | #ppiupsetalert, New Mexico -235 |
| 6:30 PM | FS1 | Xavier | Butler | 5.5 | 3 | |
| 7 PM | ESPN | Pittsburgh | Syracuse | 6.5 | 1 | Syracuse +6.5 |
| 7 PM | ACCN | NC State | Wake Forest | 1.5 | 6 | NC State -1.5 |
| 7 PM | SECN | Alabama | Missouri | 14.5 | 16 | |
| 7 PM | ESPN+ | Eastern Michigan | Ball State | -1.5 | 5 | Eastern Michigan -102 |
| 8:30 PM | FS1 | Seton Hall | St. John’s | -1.5 | 1 | |
| 9 PM | ACCN | Clemson | Georgia Tech | 11.5 | 16 | Clemson -11.5 |
| 9 PM | ESPNU | South Carolina | Georgia | 5.5 | 7 | |
| 9 PM | SECN | Arkansas | Texas A&M | -2.5 | 2 | Arkansas +116 |