#ppiupsetalertrecord: 19-21 (.475)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | FS1 | #1 Connecticut | #18 Creighton | 6.5 | 6 | |
| 7 PM | ESPN2 | #8 Kentucky | Mississippi State | 6.5 | 4 | #ppiupsetalert, Mississippi State +240 |
| 7 PM | SECN | LSU | #22 Ole Miss | 3.5 | -7 | Ole Miss +132 |
| 8 PM | ESPN+ | #15 Oklahoma | West Virginia | 12.5 | 22 | Oklahoma -12.5 |
| 9 PM | ACCN | #4 North Carolina | Louisville | 20.5 | 27 | North Carolina -20.5 |
| 9 PM | ESPNU | #5 Houston | #25 Texas Tech | 12.5 | 4 | #ppiupsetalert, Texas Tech +640 |
| 9 PM | SECN | Vanderbilt | #13 Auburn | -11.5 | -19 | Auburn -11.5 |
| 10 PM | ESPN | #12 Arizona | USC | 19.5 | 24 | Arizona -19.5 |
| 7 PM | ESPNU | Virginia | Virginia Tech | 4.5 | 4 | |
| 7 PM | ACCN | Miami (FL) | Florida State | 6.5 | 8 | |
| 7 PM | BTN | Rutgers | Nebraska | 2.5 | -4 | Nebraska +128 |
| 8 PM | LHN | Texas | UCF | 8.5 | 5 | UCF +8.5 |
| 9 PM | PAC12 | Arizona State | UCLA | 3.5 | 11 | Arizona State -3.5 |
| 9 PM | BTN | Northwestern | Maryland | 4.5 | 3 | |
| 9 PM | FS1 | DePaul | Providence | -9.5 | -7 |