#ppiupsetalertrecord: 70-78 (.473)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:15 PM | CBS | #8 Mississippi State | #9 Michigan State | -1.5 | 2 | West Rd 1 (Charlotte), #ppiupsetalert, Miss St +102 |
| 12:40 PM | TruTV | #6 BYU | #11 Duquesne | 9.5 | 3 | East Rd 1 (Omaha), Duquesne +9.5 |
| 1:30 PM | TNT | #3 Creighton | #14 Akron | 12.5 | 7 | Midwest Rd 1 (Pittsburgh), Akron +12.5 |
| 2 PM | TBS | #2 Arizona | #15 Long Beach State | 19.5 | 17 | West Rd 1 (Salt Lake City) |
| 2:45 PM | CBS | #1 North Carolina | #16 Wagner | 24.5 | 28 | West Rd 1 (Charlotte), North Carolina -24.5 |
| 3:10 PM | TruTV | #3 Illinois | #14 Morehead State | 11.5 | 14 | East Rd 1 (Omaha) |
| 4 PM | TNT | #6 South Carolina | #11 Oregon | -1.5 | 4 | Midwest Rd 1 (Pittsburgh), South Carolina -102 |
| 4:30 PM | TBS | #7 Dayton | #10 Nevada | -1.5 | 2 | West Rd 1 (Salt Lake City), Dayton -105 |
| 6:50 PM | TNT | #7 Texas | #10 Colorado State | 2.5 | -4 | Midwest Rd 1 (Charlotte), #ppiupsetalert, Colorado St +110 |
| 7:10 PM | CBS | #3 Kentucky | #14 Oakland | 13.5 | 7 | South Rd 1 (Pittsburgh), Oakland +13.5 |
| 7:25 PM | TBS | #5 Gonzaga | #12 McNeese State | 6.5 | 4 | Midwest Rd 1 (Salt Lake City) |
| 7:35 PM | TruTV | #2 Iowa State | #15 South Dakota State | 15.5 | 15 | East Rd 1 (Omaha) |
| 9:20 PM | TNT | #2 Tennessee | #15 Saint Peter’s | 21.5 | 20 | Midwest Rd 1 (Charlotte) |
| 9:40 PM | CBS | #6 Texas Tech | #11 NC State | 4.5 | -1 | South Rd 1 (Pittsburgh), #ppiupsetalert, NC State +158 |
| 9:55 PM | TBS | #4 Kansas | #13 Samford | 6.5 | -4 | Midwest Rd 1 (Salt Lake City), #ppiupsetalert, Samford +240 |
| 10:05 PM | TruTV | #7 Washington State | #10 Drake | -1.5 | -1 | East Rd 1 (Omaha) |