#ppiupsetalert record: 5-2 (.714)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11 AM | ESPN | #10 Kentucky | #6 Florida | 3.5 | -4 | #ppiupsetalert, Kentucky -154 |
| 12 PM | SECN | #24 Ole Miss | Georgia | 5.5 | 4 | |
| 12 PM | CBSSN | West Virginia | Oklahoma State | 8.5 | 1 | Oklahoma State +8.5 |
| 12 PM | ESPNU | Georgia Tech | Boston College | 7.5 | -1 | Boston College +255 |
| 12 PM | CW | Wake Forest | NC State | 5.5 | 9 | Wake Forest -5.5 |
| 12 PM | CBS | Notre Dame | North Carolina | -4.5 | -6 | |
| 12 PM | ESPN+ | Massachusetts | Richmond | 4.5 | 6 | |
| 12 PM | USA | George Washington | Dayton | -8.5 | -6 | |
| 12 PM | FS1 | Villanova | DePaul | 9.5 | 5 | DePaul +9.5 |
| 12 PM | Stony Brook | William & Mary | -5.5 | -4 | ||
| 12 PM | Northeastern | Hofstra | 3.5 | 6 | ||
| 12 PM | ESPN+ | Western Michigan | Toledo | -2.5 | -5 | |
| 1 PM | ESPN | #1 Tennessee | #23 Arkansas | 11.5 | 18 | Tennessee -11.5 |
| 1 PM | ESPN+ | New Hampshire | Vermont | -11.5 | -10 | |
| 1 PM | ESPN+ | App State | Texas State | 1.5 | -1 | |
| 1 PM | ESPN+ | Detroit Mercy | Milwaukee | -8.5 | -8 | |
| 1 PM | ESPN+ | Northern Kentucky | Green Bay | 13.5 | 21 | Northern Kentucky -12.5 |
| 1 PM | ESPN+ | Queens University | Florida Gulf Coast | -3.5 | 5 | Queens University +148 |
| 1 PM | ESPN+ | The Citadel | Chattanooga | -11.5 | -4 | |
| 1 PM | ESPN+ | Miami (OH) | Buffalo | 11.5 | 9 | |
| 2 PM | CBS | #3 Iowa State | #25 Baylor | 8.5 | 6 | |
| 2 PM | ESPN+ | #14 Houston | BYU | 9.5 | 8 | |
| 2 PM | FOX | Nebraska | #15 UCLA | 2.5 | 6 | #ppiupsetalert, Nebraska -142 |
| 2 PM | SECN | #17 Mississippi State | South Carolina | 10.5 | 7 | South Carolina +10.5 |
| 2 PM | ESPN+ | UNC Asheville | High Point | -3.5 | -1 | |
| 2 PM | ESPN+ | Gardner-Webb | Presbyterian College | 2.5 | 0 | |
| 2 PM | ESPN+ | Rice | Charlotte | 3.5 | 12 | Rice -3.5 |
| 2 PM | ESPNU | UAB | Tulsa | 12.5 | 9 | Tulsa +12.5 |
| 2 PM | ACCN | Virginia Tech | Miami (FL) | -1.5 | 5 | Virginia Tech -105 |
| 2 PM | CBSSN | Loyola (CHI) | VCU | -5.5 | -8 | |
| 2 PM | ESPN+ | Fordham | St. Bonaventure | -6.5 | -7 | |
| 2 PM | ESPN+ | Davidson | Duquesne | 4.5 | 15 | Davidson -4.5 |
| 2 PM | Rhode Island | George Mason | 1.5 | 4 | ||
| 2 PM | ESPN+ | Evansville | Indiana State | -3.5 | -5 | |
| 2 PM | ESPN+ | West Georgia | Stetson | 4.5 | 4 | |
| 2 PM | ESPN+ | Central Arkansas | Bellarmine | 4.5 | 9 | Central Arkansas -4.5 |
| 2 PM | ESPN+ | Bryant University | Maine | 2.5 | -1 | |
| 2 PM | ESPN+ | Binghamton | UMBC | -2.5 | 5 | Binghamton +126 |
| 2 PM | FS1 | St. John’s | Butler | 11.5 | 15 | St. John’s -11.5 |
| 2 PM | ESPN+ | Coastal Carolina | UL Monroe | 6.5 | 11 | Coastal Carolina -6.5 |
| 2 PM | Charleston | Towson | 6.5 | 16 | Charleston -6.5 | |
| 2 PM | North Carolina A&T | Drexel | -4.5 | -7 | ||
| 2 PM | ESPN+ | North Florida | Lipscomb | -5.5 | -1 | |
| 2 PM | North Dakota | St. Thomas-Minnesota | -5.5 | -9 | ||
| 2 PM | North Dakota State | Omaha | 12.5 | 14 | ||
| 2 PM | ESPN+ | Eastern Michigan | Northern Illinois | 7.5 | 12 | |
| 2 PM | ESPN+ | Kent State | Ball State | 10.5 | 15 | Kent State -10.5 |
| 2 PM | ESPN+ | Florida International | Western Kentucky | -5.5 | -9 | |
| 2:15 PM | CW | SMU | #4 Duke | -7.5 | 4 | #ppiupsetalert, SMU +255 |
| 2:30 PM | ESPN2 | #16 Cincinnati | Arizona | 2.5 | 8 | #ppiupsetalert, Cincinnati -154 |
| 3 PM | ESPN+ | Georgia Southern | South Alabama | -5.5 | 0 | Georgia Southern +180 |
| 3 PM | ESPN+ | Oakland | Robert Morris | 5.5 | 5 | |
| 3 PM | ESPN+ | Cleveland State | IU Indianapolis | 9.5 | 16 | Cleveland State -9.5 |
| 3 PM | ESPN+ | Jacksonville | Austin Peay | 5.5 | 3 | |
| 3 PM | ESPN+ | Western Carolina | Samford | -12.5 | -5 | Western Carolina +11.5 |
| 3:15 PM | ESPN+ | East Texas A&M | McNeese | -16.5 | -10 | East Texas A&M +16.5 |
| 4 PM | SECN | #2 Auburn | Missouri | 18.5 | 20 | |
| 4 PM | CBSSN | TCU | Kansas State | 3.5 | -1 | Kansas State +140 |
| 4 PM | ACCN | Virginia | Louisville | -5.5 | -2 | Virginia +5.5 |
| 4 PM | ESPN+ | Morgan State | South Carolina State | -5.5 | -2 | |
| 4 PM | ESPN+ | Norfolk State | Maryland-Eastern Shore | 17.5 | 20 | |
| 4 PM | ESPN+ | Valparaiso | Northern Iowa | -4.5 | -3 | |
| 4 PM | CBS | Boise State | San Diego State | 3.5 | 3 | |
| 4 PM | Alabama State | Mississippi Valley State | 22.5 | 7 | ||
| 4 PM | ESPN+ | Albany | Umass Lowell | -1.5 | -6 | UMass Lowell -1.5 |
| 4 PM | ESPN+ | Northern Arizona | Weber State | 2.5 | 3 | |
| 4 PM | ESPN+ | Sacramento State | Portland State | -4.5 | -6 | |
| 4 PM | ESPN+ | Northern Colorado | Idaho State | 8.5 | 9 | |
| 4 PM | ESPN+ | Old Dominion | Southern Miss | 2.5 | 0 | |
| 4 PM | ESPN+ | Marshall | Troy | -1.5 | 0 | |
| 4 PM | ESPN+ | James Madison | Arkansas State | -1.5 | -5 | Arkansas State -1.5 |
| 4 PM | Delaware | Monmouth | 5.5 | 9 | ||
| 4 PM | ESPN+ | Utah Valley | Abilene Christian | 8.5 | 9 | |
| 4 PM | ESPN+ | UNC Greensboro | Furman | 1.5 | -7 | Furman -104 |
| 4 PM | ESPN+ | East Tennessee State | Wofford | 4.5 | 8 | |
| 4 PM | ESPN+ | Tennessee Tech | Morehead State | 2.5 | -1 | |
| 4 PM | ESPN+ | New Mexico State | Louisiana Tech | -2.5 | -5 | |
| 4:30 PM | ESPN+ | Radford | Winthrop | -1.5 | 7 | Radford +110 |
| 4:30 PM | ESPN+ | Northwestern State | Nicholls State | 1.5 | -2 | |
| 4:30 PM | ESPN+ | Coppin State | North Carolina Central | -8.5 | 1 | Coppin State +310 |
| 4:30 PM | ESPN+ | SE Louisiana | Texas A&M-Corpus Christi | -2.5 | 3 | SE Louisiana +114 |
| 4:30 PM | ESPN2 | LSU | Vanderbilt | -2.5 | -4 | |
| 4:30 PM | ESPN+ | VMI | Mercer | -5.5 | -2 | |
| 4:30 PM | ESPN+ | UT Martin | Southeast Missouri State | 2.5 | -1 | |
| 4:30 PM | ESPN+ | Tennessee State | Little Rock | 1.5 | -6 | Little Rock -105 |
| 4:30 PM | ESPN+ | SIU-Edwardsville | Lindenwood | 7.5 | 14 | SIU-Edwardsville -7.5 |
| 4:30 PM | ESPN+ | Eastern Illinois | Western Illinois | 2.5 | 6 | |
| 5 PM | ESPN+ | Belmont | UIC | 6.5 | 4 | |
| 5 PM | Air Force | Wyoming | -3.5 | -10 | Wyoming -3.5 | |
| 5 PM | Alabama A&M | Arkansas-Pine Bluff | 8.5 | 0 | Arkansas-Pine Bluff +320 | |
| 5 PM | ESPN+ | Idaho | Montana | -2.5 | -2 | |
| 5 PM | ESPN+ | Eastern Washington | Montana State | -1.5 | 2 | |
| 5 PM | ESPN+ | Kennesaw State | Jacksonville State | 1.5 | 2 | |
| 5:30 PM | Prairie View A&M | Grambling State | -2.5 | 2 | Prairie View A&M +118 | |
| 5:30 PM | ESPN+ | North Alabama | Eastern Kentucky | 6.5 | 5 | |
| 6 PM | SECN | #5 Alabama | #12 Oklahoma | 13.5 | 7 | Oklahoma +13.5 |
| 6 PM | ESPN+ | Arizona State | Colorado | 6.5 | 5 | |
| 6 PM | ESPNU | Tulane | UTSA | 5.5 | 2 | UTSA +5.5 |
| 6 PM | ACCN | Florida State | Syracuse | 8.5 | 16 | Florida State -8.5 |
| 6 PM | UNLV | San Jose State | 9.5 | 10 | ||
| 6 PM | Texas Southern | Southern University | -1.5 | -1 | ||
| 6 PM | Florida A&M | Bethune-Cookman | -4.5 | 3 | Florida A&M +160 | |
| 6 PM | ESPN+ | New Orleans | UT-Rio Grande Valley | -8.5 | -5 | |
| 6 PM | ESPN+ | Stephen F. Austin | Incarnate Word | 5.5 | 6 | |
| 6 PM | ESPN+ | Cal State Northridge | UC Davis | 8.5 | 7 | |
| 6 PM | ESPN+ | Oregon State | San Diego | 15.5 | 25 | Oregon State -15.5 |
| 6 PM | Kansas City | Oral Roberts | 7.5 | 6 | ||
| 6 PM | CBSSN | Liberty | Middle Tennessee | 7.5 | 4 | |
| 6:30 PM | ESPN2 | Pittsburgh | Stanford | 9.5 | 5 | Stanford +9.5 |
| 8 PM | SECN | #13 Texas A&M | Texas | 6.5 | 9 | |
| 8 PM | FOX | USC | Michigan | -5.5 | -4 | |
| 8 PM | ESPNU | Howard | Delaware State | 7.5 | -1 | Delaware State +245 |
| 8 PM | CBSSN | Bradley | Missouri State | 11.5 | 13 | |
| 8 PM | ESPN+ | Tarleton State | UT-Arlington | -5.5 | 0 | Tarleton State +5.5 |
| 8 PM | ESPN+ | Grand Canyon | Southern Utah | 16.5 | 11 | Southern Utah +16.5 |
| 8 PM | ESPN+ | California Baptist | Seattle | 3.5 | 6 | |
| 8 PM | South Dakota | Denver | 9.5 | 10 | ||
| 8:30 PM | ESPN2 | Clemson | California | 14.5 | 19 | Clemson -14.5 |
| 9 PM | ESPN+ | Loyola Marymount | #19 Gonzaga | -15.5 | -5 | Loyola Marymount +15.5 |
| 9 PM | Utah State | Fresno State | 22.5 | 29 | Utah State -22.5 | |
| 9 PM | ESPN+ | Cal State Fullerton | UC San Diego | -12.5 | -14 | |
| 9 PM | ESPN+ | UTEP | Sam Houston State | 5.5 | 7 | |
| 9:30 PM | ESPN+ | Cal State Bakersfield | Long Beach State | 5.5 | 3 | |
| 10 PM | ESPN+ | UC Irvine | UC Riverside | 8.5 | 12 | |
| 10 PM | ESPN+ | Portland | Saint Mary’s | -18.5 | -17 | |
| 11:59 PM | Hawaii | Cal Poly | 5.5 | 8 |