#ppiupsetalert record: 11-9 (.550)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | FS1 | Xavier | Villanova | 2.5 | 2 | |
| 7 PM | SECN | #1 Auburn | #15 Mississippi State | 7.5 | 4 | #ppiupsetalert, Mississippi State +7.5 |
| 7 PM | ESPNU | #4 Alabama | #21 Ole Miss | 11.5 | 7 | Ole Miss +11.5 |
| 7 PM | CBSSN | DePaul | #7 Marquette | -12.5 | -13 | |
| 7 PM | ESPN2 | #8 Kentucky | #11 Texas A&M | 6.5 | 5 | |
| 7 PM | Peacock | Indiana | #19 Illinois | -5.5 | 0 | #ppiupsetalert, Indiana +205 |
| 7 PM | ACCN | Syracuse | Louisville | -8.5 | -8 | |
| 7 PM | ESPN+ | VCU | Saint Louis | 9.5 | 11 | |
| 7:30 PM | ESPN+ | Belmont | Valparaiso | 6.5 | 11 | Belmont -6.5 |
| 7:30 PM | Peacock | St. John’s | Georgetown | 9.5 | 15 | St. John’s -9.5 |
| 8 PM | ESPN+ | Northern Iowa | Evansville | 13.5 | 13 | |
| 8:30 PM | FS1 | Creighton | Providence | 9.5 | 7 | |
| 9 PM | ESPN | #3 Duke | Miami (FL) | 23.5 | 27 | Duke -23.5 |
| 9 PM | ESPNU | #5 Florida | Missouri | 10.5 | 16 | Florida -10.5 |
| 9 PM | Peacock | #24 Wisconsin | Ohio State | 6.5 | 5 | |
| 9 PM | CBSSN | Kansas State | Texas Tech | -6.5 | -5 | |
| 9 PM | ESPN+ | BYU | Oklahoma State | 13.5 | 3 | Oklahoma State +13.5 |
| 9 PM | ACCN | Georgia Tech | Clemson | -5.5 | -8 | |
| 9 PM | Boise State | Wyoming | 13.5 | 13 | ||
| 9 PM | SECN | LSU | Arkansas | -1.5 | 0 | |
| 10 PM | San Jose State | New Mexico | -9.5 | -13 | New Mexico -9.5 | |
| 10 PM | Nevada | Air Force | 19.5 | 24 | Nevada -19.5 | |
| 10:30 PM | FS1 | USC | Iowa | 2.5 | 3 | |
| 11 PM | ESPN | Arizona | #25 Baylor | 5.5 | 2 | #ppiupsetalert, Baylor +172 |
| 11 PM | ESPNU | Arizona State | UCF | 3.5 | 3 | |
| 11 PM | CBSSN | San Diego State | Colorado State | 6.5 | 7 |