#ppiupsetalert record: 21-19 (.525)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | #8 Tennessee | #5 Florida | 2.5 | -3 | #ppiupsetalert, Tennessee -150 |
| 12 PM | CBSSN | #15 St. John’s | Providence | 13.5 | 19 | St. John’s -13.5 |
| 12 PM | ESPN2 | Wake Forest | Pittsburgh | 2.5 | 1 | |
| 12 PM | BTN | Minnesota | Washington | 5.5 | 4 | |
| 12:30 PM | USA | St. Bonaventure | Fordham | 10.5 | 11 | |
| 1 PM | SECN | #14 Mississippi State | #20 Missouri | 6.5 | 8 | |
| 1 PM | CBS | Arizona State | Arizona | -6.5 | -3 | |
| 1 PM | FOX | Villanova | Creighton | 2.5 | -1 | Creighton +108 |
| 1:30 PM | CW | NC State | Clemson | -4.5 | -9 | |
| 2 PM | ESPN | #23 Ole Miss | #1 Auburn | -5.5 | -8 | |
| 2 PM | ESPN2 | #3 Iowa State | Kansas State | 14.5 | 15 | |
| 2 PM | FS1 | Northwestern | #17 Wisconsin | -4.5 | -3 | |
| 2 PM | ACCN | Boston College | Florida State | -5.5 | -7 | |
| 2 PM | CBSSN | Loyola (CHI) | Saint Joseph’s | -1.5 | 1 | |
| 2 PM | ESPN+ | Duquesne | Massachusetts | 3.5 | 4 | |
| 2 PM | ESPNU | Southern Illinois | Drake | -6.5 | -8 | |
| 2:30 PM | La Salle | George Washington | -2.5 | -2 | ||
| 3 PM | ESPN+ | Oklahoma State | Utah | 1.5 | 3 | |
| 3 PM | ESPN+ | Missouri State | Murray State | -2.5 | -3 | |
| 3 PM | ESPN+ | Middle Tennessee | UTEP | 3.5 | 4 | |
| 3 PM | ESPN+ | Western Kentucky | New Mexico State | 2.5 | -2 | New Mexico State +126 |
| 3 PM | ESPN+ | UIC | Indiana State | 7.5 | 13 | UIC -7.5 |
| 3:30 PM | SECN | Oklahoma | #24 Vanderbilt | 3.5 | 1 | #ppiupsetalert, Oklahoma +162 |
| 3:30 PM | FOX | Rutgers | Michigan | -5.5 | -9 | Michigan -4.5 |
| 3:45 PM | CW | Georgia Tech | #21 Louisville | -7.5 | -13 | Louisville -7.5 |
| 4 PM | ESPN2 | #4 Alabama | Georgia | 12.5 | 11 | |
| 4 PM | ESPN | Baylor | #11 Kansas | 2.5 | -3 | #ppiupsetalert, Baylor -128 |
| 4 PM | Boise State | Fresno State | 19.5 | 18 | ||
| 4 PM | ESPN+ | UCF | BYU | -4.5 | 4 | UCF +154 |
| 4 PM | ACCN | Virginia | Virginia Tech | 3.5 | 3 | |
| 4 PM | CBSSN | VCU | Richmond | 19.5 | 25 | VCU -19.5 |
| 4 PM | ESPN+ | Davidson | George Mason | 3.5 | -1 | George Mason +128 |
| 4:30 PM | Peacock | USC | #7 Michigan State | -3.5 | -8 | Michigan State -3.5 |
| 5 PM | ESPN+ | Illinois State | Valparaiso | 8.5 | 9 | |
| 5 PM | San Jose State | Air Force | 9.5 | 14 | San Jose State -9.5 | |
| 5 PM | ESPN+ | Jacksonville State | Liberty | -4.5 | -1 | Jacksonville State +150 |
| 5 PM | ESPN+ | Kennesaw State | Florida International | 7.5 | 12 | Kennesaw State -7.5 |
| 6 PM | ESPN2 | #6 Houston | #22 Texas Tech | 9.5 | 7 | |
| 6 PM | ACCN | SMU | Stanford | 6.5 | 5 | |
| 6 PM | SECN | LSU | Texas | -5.5 | 1 | LSU +200 |
| 6 PM | ESPN+ | San Diego | Loyola Marymount | -6.5 | -14 | Loyola Marymount -6.5 |
| 6:30 PM | ESPN | #2 Duke | North Carolina | 13.5 | 12 |