#ppiupsetalert record: 30-25 (.545)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | SECN | Vanderbilt | #1 Auburn | -8.5 | -7 | |
| 7 PM | ESPN2 | #22 Mississippi State | #4 Florida | -1.5 | 1 | #ppiupsetalert, Mississippi State -118 |
| 7 PM | ESPN | #15 Kentucky | #5 Tennessee | -2.5 | -10 | Tennessee -2.5 |
| 7 PM | Peacock | #20 Michigan | #7 Purdue | 2.5 | 1 | #ppiupsetalert, Michigan -128 |
| 7 PM | ESPN+ | UCF | #10 Iowa State | -7.5 | -4 | #ppiupsetalert, UCF +260 |
| 7 PM | ESPN+ | Cincinnati | Utah | 8.5 | 6 | |
| 7 PM | CBSSN | West Virginia | BYU | 2.5 | 2 | |
| 7 PM | ACCN | Miami (FL) | Syracuse | 1.5 | -3 | Syracuse +110 |
| 7 PM | ESPN+ | Richmond | Loyola (CHI) | -5.5 | -6 | |
| 7 PM | ESPN+ | Ball State | Eastern Michigan | 4.5 | 4 | |
| 8 PM | ESPN+ | Kansas State | #13 Arizona | -3.5 | -2 | #ppiupsetalert, Kansas State +136 |
| 8 PM | ESPN+ | Saint Louis | George Mason | 1.5 | -4 | George Mason -102 |
| 8 PM | ESPN+ | Northern Iowa | Indiana State | 8.5 | 9 | |
| 8 PM | ESPN+ | Murray State | UIC | 3.5 | 0 | UIC +130 |
| 8 PM | Peacock | Illinois | UCLA | 6.5 | 1 | UCLA +6.5 |
| 8:30 PM | Peacock | #18 Marquette | DePaul | 16.5 | 21 | Marquette -16.5 |
| 9 PM | ESPN | Texas | #2 Alabama | -4.5 | -10 | Alabama -4.5 |
| 9 PM | SECN | #8 Texas A&M | Georgia | 8.5 | 17 | Texas A&M -8.5 |
| 9 PM | Peacock | #11 Michigan State | Indiana | 10.5 | 10 | |
| 9 PM | ESPN2 | #17 Kansas | Colorado | 17.5 | 17 | |
| 9 PM | CBSSN | #24 Creighton | Connecticut | 3.5 | 9 | Creighton -3.5 |
| 9 PM | ESPN+ | Pepperdine | Loyola Marymount | -2.5 | -5 | |
| 9 PM | ACCN | SMU | Pittsburgh | 3.5 | 10 | SMU -3.5 |
| 9 PM | BTN | USC | Penn State | 3.5 | 6 | |
| 10 PM | UNLV | Air Force | 13.5 | 19 | UNLV -13.5 | |
| 11 PM | FS1 | Utah State | Colorado State | 5.5 | 11 | Utah State -5.5 |
| 11 PM | CBSSN | San Jose State | San Diego State | -9.5 | -13 | San Diego State -9.5 |
| 11 PM | BTN | Oregon | Northwestern | 9.5 | 19 | Oregon -9.5 |
| 11 PM | ESPN2 | Saint Mary’s | Santa Clara | 10.5 | 12 |