#ppiupsetalert record: 33-34 (.493)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | FS1 | Connecticut | Villanova | 8.5 | 9 | |
| 7 PM | ESPN2 | #2 Florida | Oklahoma | 13.5 | 12 | |
| 7 PM | SECN | #21 Mississippi State | #7 Texas A&M | 2.5 | 1 | #ppiupsetalert, Miss St -137 |
| 7 PM | Peacock | #14 Michigan State | #13 Purdue | 3.5 | 4 | #ppiupsetalert, Michigan St -164 |
| 7 PM | ACCN | Pittsburgh | Syracuse | 10.5 | 10 | |
| 7 PM | CBSSN | Davidson | Loyola (CHI) | 2.5 | 4 | |
| 8 PM | ESPN+ | #8 Iowa State | Colorado | 18.5 | 17 | |
| 8 PM | ESPN+ | TCU | #9 Texas Tech | -7.5 | -7 | |
| 8 PM | Peacock | Xavier | Butler | 7.5 | 8 | |
| 8:30 PM | FS1 | #11 Wisconsin | Illinois | 3.5 | 10 | Wisconsin -3.5 |
| 8:30 PM | Wyoming | Air Force | 8.5 | 13 | Wyoming -8.5 | |
| 9 PM | ESPN2 | Arizona State | #5 Houston | -11.5 | -11 | |
| 9 PM | CBSSN | #16 Marquette | Seton Hall | 18.5 | 23 | Marquette -18.5 |
| 9 PM | ESPN | BYU | #23 Kansas | 2.5 | 0 | #ppiupsetalert, BYU -150 |
| 9 PM | ACCN | Boston College | Virginia Tech | -1.5 | 1 | |
| 9 PM | Colorado State | Nevada | 3.5 | 5 | ||
| 9 PM | SECN | LSU | South Carolina | 2.5 | 1 | |
| 10:30 PM | FS1 | UCLA | Minnesota | 11.5 | 11 | |
| 11 PM | CBSSN | San Diego State | Fresno State | 18.5 | 21 |