#ppiupsetalert record: 38-35 (.521)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN2 | Virginia | #13 Clemson | -7.5 | -8 | |
| 12 PM | BTN | Penn State | #16 Maryland | -5.5 | -4 | #ppiupsetalert, Penn State +180 |
| 12 PM | ESPN | North Carolina | Miami (FL) | 18.5 | 20 | |
| 12 PM | CW | Virginia Tech | Syracuse | 3.5 | 3 | |
| 12 PM | Fordham | Saint Joseph’s | -8.5 | -5 | Fordham +8.5 | |
| 12 PM | CBS | Providence | Connecticut | -6.5 | -8 | |
| 12 PM | FOX | Villanova | Butler | 6.5 | 7 | |
| 1 PM | ABC | #17 Kentucky | #1 Auburn | -5.5 | -12 | Auburn -5.5 |
| 1 PM | SECN | South Carolina | Arkansas | 1.5 | 6 | South Carolina -1.5 |
| 2 PM | ESPN | Kansas | #10 Texas Tech | 4.5 | 8 | #ppiupsetalert, Kansas -192 |
| 2 PM | ESPN+ | Duquesne | George Mason | -2.5 | -6 | George Mason -2.5 |
| 2 PM | CBSSN | Dayton | Richmond | 13.5 | 19 | Dayton -13.5 |
| 2 PM | New Mexico | Air Force | 21.5 | 25 | New Mexico -21.5 | |
| 2 PM | BTN | Nebraska | Minnesota | 7.5 | 7 | |
| 2 PM | ESPN2 | Ole Miss | Oklahoma | 7.5 | 7 | |
| 2 PM | ESPN+ | Bowling Green | Ball State | 2.5 | 0 | Ball State +114 |
| 2 PM | ESPN+ | Florida International | Jacksonville State | -3.5 | -6 | |
| 2:15 PM | CBS | #7 St. John’s | Seton Hall | 20.5 | 21 | |
| 3 PM | ACCN | Georgia Tech | NC State | 3.5 | 3 | |
| 3:30 PM | SECN | #24 Mississippi State | LSU | 11.5 | 15 | Mississippi State -11.5 |
| 4 PM | ESPN | #5 Tennessee | #6 Alabama | 4.5 | 9 | Tennessee -4.5 |
| 4 PM | ESPN+ | TCU | UCF | 3.5 | 1 | UCF +3.5 |
| 4 PM | CBSSN | Saint Louis | Loyola (CHI) | 2.5 | 3 | |
| 4 PM | FS1 | Colorado State | Utah State | 10.5 | -1 | Utah State +320 |
| 4 PM | BTN | Oregon | USC | 6.5 | 12 | Oregon -7.5 |
| 4 PM | ESPN+ | Sacramento State | Montana State | -2.5 | -6 | |
| 4 PM | ESPN+ | UTEP | Middle Tennessee | -2.5 | -1 | |
| 4:30 PM | CBS | #4 Houston | Cincinnati | 13.5 | 16 | |
| 4:30 PM | FOX | Xavier | Creighton | 1.5 | 3 | |
| 5 PM | ACCN | Stanford | SMU | 1.5 | 4 | |
| 5:15 PM | CW | Wake Forest | Notre Dame | 9.5 | 17 | Wake Forest -9.5 |
| 5:30 PM | ESPN+ | Sam Houston State | Louisiana Tech | 2.5 | -3 | Louisiana Tech +114 |
| 6 PM | SECN | Vanderbilt | #14 Missouri | -2.5 | 3 | #ppiupsetalert, Vanderbilt +114 |
| 6 PM | ESPN2 | #19 Louisville | Pittsburgh | 10.5 | 13 | |
| 6 PM | ESPN+ | Massachusetts | Rhode Island | 1.5 | -1 | Rhode Island +104 |
| 6 PM | ESPN+ | George Washington | La Salle | 9.5 | 11 | |
| 6 PM | Peacock | Washington | Indiana | -1.5 | -3 | |
| 6 PM | ESPN+ | New Mexico State | Western Kentucky | 3.5 | 11 | New Mexico State -3.5 |
| 7 PM | ACCN | #2 Duke | Florida State | 21.5 | 12 | Florida State +21.5 |
| 7 PM | Fresno State | Boise State | -16.5 | -14 | ||
| 7 PM | ESPN+ | Utah | Arizona State | 7.5 | 8 | |
| 8 PM | Peacock | Georgetown | #21 Marquette | -8.5 | -12 | Marquette -8.5 |
| 8 PM | ESPN+ | Baylor | Oklahoma State | 12.5 | 6 | Oklahoma State +12.5 |
| 8 PM | CBSSN | Wyoming | San Diego State | -6.5 | -7 | |
| 8 PM | ESPN2 | Texas | Georgia | 5.5 | -1 | Georgia +5.5 |
| 8 PM | ESPN+ | Pacific | Santa Clara | -13.5 | -12 | |
| 8:30 PM | SECN | #3 Florida | #12 Texas A&M | 9.5 | 9 | |
| 9 PM | ESPN | #9 Iowa State | #22 Arizona | 5.5 | 3 | #ppiupsetalert, Arizona +198 |
| 10 PM | CBSSN | #23 Saint Mary’s | Oregon State | 11.5 | 14 | |
| 10 PM | ESPN2 | #25 BYU | West Virginia | 9.5 | 6 | West Virginia +9.5 |
| 10 PM | ESPNU | California | Boston College | 7.5 | 5 | Boston College +7.5 |
| 10 PM | ESPN+ | San Diego | Portland | -2.5 | -5 | Portland -2.5 |
| 10 PM | ESPN+ | Pepperdine | Washington State | -4.5 | -5 | |
| 11 PM | ESPN | San Francisco | Gonzaga | -9.5 | -3 | San Francisco +310 |