#ppiupsetalert record: 39-38 (.507)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6 PM | ESPN+ | Southern Miss | Coastal Carolina | 3.5 | 3 | Sun Belt – Rd 1 |
| 6 PM | SECN | South Carolina | Georgia | -1.5 | -1 | |
| 7 PM | ESPN+ | UTSA | #16 Memphis | -8.5 | -14 | Memphis -8.5 |
| 7 PM | Peacock | #18 Purdue | Rutgers | 10.5 | 12 | |
| 7 PM | ESPN2 | #19 Kentucky | LSU | 11.5 | 13 | |
| 7 PM | ESPN+ | Loyola (MD) | Lehigh | 2.5 | 3 | Patriot – Rd 1 |
| 7 PM | ESPN+ | Lafayette | Holy Cross | 6.5 | 3 | Patriot – Rd 1, Holy Cross +6.5 |
| 7 PM | ESPN+ | Northern Kentucky | Detroit Mercy | 13.5 | 12 | Horizon – Rd 1 |
| 7 PM | ESPN+ | Oakland | Green Bay | 10.5 | 17 | Oakland -10.5 |
| 7 PM | ACCN | Georgia Tech | Miami (FL) | 9.5 | 10 | |
| 7 PM | ESPNU | Virginia Tech | North Carolina | -8.5 | -9 | |
| 7 PM | ESPN+ | Dayton | Saint Louis | 7.5 | 8 | |
| 7 PM | CBSSN | Duquesne | VCU | -9.5 | -10 | |
| 7 PM | FS1 | Seton Hall | Creighton | -8.5 | -9 | |
| 8 PM | SECN | #25 Mississippi State | Texas | 7.5 | 12 | Mississippi State -7.5 |
| 8 PM | ESPN+ | Wright State | IU Indianapolis | 9.5 | 10 | Horizon – Rd 1 |
| 8 PM | ESPN+ | TCU | Baylor | -3.5 | 0 | TCU +3.5 |
| 8 PM | Peacock | Georgetown | Villanova | -5.5 | -4 | |
| 8:30 PM | ESPN+ | Louisiana | UL Monroe | 5.5 | 4 | Sun Belt – Rd 1 |
| 9 PM | ESPN | #22 Texas A&M | #1 Auburn | -4.5 | -4 | #ppiupsetalert, Texas A&M +152 |
| 9 PM | ESPN2 | #10 Iowa State | #23 BYU | 9.5 | 7 | |
| 9 PM | ESPN+ | Utah | West Virginia | 3.5 | 3 | |
| 9 PM | ACCN | Virginia | Florida State | 4.5 | 3 | |
| 9 PM | ESPNU | SMU | Syracuse | 12.5 | 14 | |
| 9 PM | Colorado State | San Jose State | 16.5 | 17 | ||
| 9 PM | CBSSN | Nevada | New Mexico | -1.5 | -6 | New Mexico -1.5 |
| 9 PM | Air Force | Boise State | -15.5 | -16 | ||
| 9 PM | FS1 | Oregon | Indiana | 6.5 | 8 | |
| 9 PM | Peacock | Ohio State | Nebraska | 6.5 | 5 | |
| 10 PM | Fresno State | Wyoming | -1.5 | -2 | ||
| 10 PM | SECN | Vanderbilt | Arkansas | 7.5 | 15 | Vanderbilt -7.5 |
| 11 PM | ESPN | #24 Arizona | Arizona State | 18.5 | 14 | Arizona State +18.5 |
| 11 PM | CBSSN | UNLV | San Diego State | -2.5 | -4 |